Sökning: "Isoenzymes"
Visar resultat 16 - 20 av 36 avhandlingar innehållade ordet Isoenzymes.
16. Nitric Oxide Synthase in Pancreatic Islets During Trauma and Parenteral Feeding
Sammanfattning : The influence of trauma (acute pancreatitis) or total parenteral nutrition (TPN) on pancreatic islet hormone secretion in relation to islet expression of inducible nitric oxide synthase (iNOS) was investigated. Acute pancreatitis resulted in an impaired glucose-stimulated insulin secretion (GSIS) which was found to be parallelled by a marked expression of iNOS and an exaggerated NO production in the pancreatic islets. LÄS MER
17. Studies on molecular properties and functional regulation of terminal leukotriene C4 synthases and cysteinyl-leukotriene receptor signalling in human endothelium
Sammanfattning : The transformation of the unstable intermediate leukotriene (LT) A4 into the glutathione conjugate LTC4, the parent compound of LTD4 and LTE4, is catalysed by leukotriene C4 synthase (LTC4S) as well as microsomal glutathione S-transferase type 2 (MGST2) and type 3 (MGST3). Together, these eicosanoids also known as cysteinyl leukotrienes (cys-LT) are key mediators of immediate hypersensitivity reactions. LÄS MER
18. Functional studies of the TDH and GPD gene-products in the glycolytic flux and glycerol metabolism of Saccharomyces cerevisiae
Sammanfattning : This thesis focuses on the physiology and control of the glycolysis and glycerol metabolism in the yeast Sacchromyces cerevisiae. The study is based on the relation ship between the first two reactions around the branch-point of the upper and lower part of glycolysis and the glycerol pathway. LÄS MER
19. Catalysis and Site-Specific Modification of Glutathione Transferases Enabled by Rational Design
Sammanfattning : This thesis describes the rational design of a novel enzyme, a thiolester hydrolase, derived from human glutathione transferase (GST) A1-1 by the introduction of a single histidine residue. The first section of the thesis describes the design and the determination of the reaction mechanism. LÄS MER
20. Cytochrome P450 2C9, 2C19 and 2D6 genetic polymorphisms : evaluation of genotyping as a tool for individualised treatment
Sammanfattning : Recent advances in the understanding of drug metabolism and the molecular biology of CYPs have generated great expectations regarding the use of pharmacogenetic testing as a tool to individualize drug treatment. The individual pharmacogenetic constitution might in principle predict the response to drugs, hormones and toxins. LÄS MER