Sökning: "Isl1"
Visar resultat 1 - 5 av 14 avhandlingar innehållade ordet Isl1.
1. Transcriptional regulation of thyroid development possible interplay of endoderm- and mesoderm-derived morphogenetic signals
Sammanfattning : Congenital hypothyroidism (CH) affects 1 in 3000 children and is the major cause of treatable mental retardation. Most cases are due to malformations of the gland, collectively named thyroid dysgenesis. The disease results from defective thyroid organogenesis during embryonic life. LÄS MER
2. Neuronal Development in the Embryonic Retina : Focus on the Characterization, Generation and Development of Horizontal Cell Subtypes
Sammanfattning : Horizontal cells are retinal interneurons that modulate the output from photoreceptors. Two horizontal cell (HC) subtypes are commonly identified in the vertebrate retina: axon-bearing and axon-less HCs. LÄS MER
3. Mechanisms by which variants in the TCF7L2 gene increase the risk of developing Type 2 diabetes
Sammanfattning : Type 2 diabetes mellitus (T2DM) is a heterogeneous disease with a multifactorial aetiology comprising of genetic and environmental factors. The common variant most highly associated with T2DM known to date is a SNP rs7903146 in the TCF7L2 gene. However, the role TCF7L2 plays in the development of T2DM was unclear. LÄS MER
4. Embryonic and adult cardiac stem cells : molecular, electrophysical and immunological characteristics for cardiac repair
Sammanfattning : Background: The concept of myocardial regeneration by means of stimulating the endogenous regenerative potential in situ is an attractive approach. This offers distinct advantages to stem cell implantation where the problems with engraftment and immune rejection are avoided. LÄS MER
5. Embryonic Stem Cells: Differentiation into Insulin Producing Cells and Elimination of Damaged Proteins
Sammanfattning : This thesis includes two different parts: One focusing on how to induce human embryonic stem cells (hESCs) to differentiate into insulin producing cells by following the normal pancreatic development pathway. These cells have then the potential to be an unlimited source for diabetes regenerative medicine. LÄS MER