Sökning: "Iscoms"
Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet Iscoms.
1. Production and delivery of recombinant subunit vaccines
Sammanfattning : Recombinant strategies are today dominating in thedevelopment of modern subunit vaccines. This thesis describesstrategies for the production and recovery of protein subunitimmunogens, and how genetic design of the expression vectorscan be used to adapt the immunogens for incorporation intoadjuvant systems. LÄS MER
2. The development of a new combined adjuvant vector for mucosal immunization CTA1-DD/ISCOM
Sammanfattning : The CTA1-DD/ISCOMs vector is a rationally designed mucosal adjuvant that was developed to host the distinctive properties of either adjuvant alone or in a combination that hosted additive enhancing effects on mucosal immune responses. Here I demonstrate that CTA1-DD can be incorporated into the ISCOM with greatly augmented immunogenicity of both incorporated and admixed antigen. LÄS MER
3. Development and evaluation of new generation vaccines against bovine respiratory syncytial virus
Sammanfattning : Bovine respiratory syncytial virus (BRSV) is a major cause of respiratory disease in cattle worldwide. Improved BRSV vaccines are needed, with better efficacy and longer duration of protection, in particular when used in calves with specific maternally derived antibodies (MDA). LÄS MER
4. Design, production and characterization of synthetic immunogens : application on Plasmodium falciparum malaria antigens
Sammanfattning : The development of synthetic subunit vaccines is presently one of the major strategies to construct vaccines against infectious diseases. Such vaccines are based on isolated and characterized immunogens and should include appropriate B- and T-cell epitopes. LÄS MER
5. Rational and combinatorial protein engineering for vaccine delivery and drug targeting
Sammanfattning : This thesis describes recombinant proteins that have been generated by rational and combinatorial protein engineering strategies for use in subunit vaccine delivery and tumor targeting.In a first series of studies, recombinant methods for incorporating immunogens into an adjuvant formulation, e.g. LÄS MER