Sökning: "Irreversible"

Visar resultat 1 - 5 av 288 avhandlingar innehållade ordet Irreversible.

1. 1. Irreversible electroporation of pancreatic adenocarcinoma

   Författare :Christopher Månsson; Britt-Marie Karlson; Anders Nilsson; Per Hellman; Sara Regnér; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pancreatic Neoplasms; Electroporation; Interventional Ultrasonography; CA 19-9.;

   Sammanfattning : Pancreatic cancer (PC) is a severe diagnosis with poor prognosis. Radical surgery is the only treatment that can possibly lead to a cure, and even with surgery, the 5-year survival is only 20%–25%. The majority of patients cannot be resected due to metastases or having a tumour that is too advanced locally (LAPC) with encasement of blood-vessels. LÄS MER

3. 2. Irreversible electroporation in the liver

   Författare :David Stillström; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Introduction: Malignant tumours in the liver are divided into primary liver cancers and liver metastases. Among primary liver cancers, hepatocellular carcinoma (HCC) accounts for 75-85% and is globally the fourth most common cause of cancer related death. Colorectal cancer (CRC) is the second most common cause of cancer related death. LÄS MER

4. 3. Pharmacodynamic Modelling of Irreversible and Reversible Gastric Proton Pump Inhibitors

   Författare :Angela Äbelö; Mats Karlsson; Michael Looby; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacokinetics Pharmacotherapy; Farmakokinetik Farmakoterapi; PHARMACY; FARMACI;

   Sammanfattning : Acid related diseases like GERD, duodenal-and gastric ulcers and H. Pylori-positive peptic ulcer disease are primarily managed by reducing gastric acidity. Irreversible proton pump inhibitors (PPIs) inhibit gastric acid secretion effectively throughout the day by irreversibly inhibiting the gastric proton pump, H+, K+-ATPase, in the parietal cells. LÄS MER

5. 4. On noise and hearing loss : Prevalence and reference data

   Författare :Magnus Johansson; Stig Arlinger; Einar Laukli; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; irreversible occupational disease; noise-induced hearing; noise-induced measurements OAE ; spontaneous otoacoustic emissions SOAE ; transient evoked otoacoustic emissions TEOAE ; distortion product otoacoustic emissions DPOAE ; Audiology; Audiologi;

   Sammanfattning : Noise exposure is one of the most prevalent causes of irreversible occupational disease in Sweden and in many other countries. In hearing conservation programs, aimed at preventing noise-induced hearing loss, audiometry is an important instrument to highlight the risks and to assess the effectiveness of the program. LÄS MER

7. 5. In vitro and in vivo studies of Bruton tyrosine kinase (BTK) mutations and inhibition

   Författare :Hernando Yesid Estupiñán Velásquez; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Bruton tyrosine kinase (BTK) is a non-receptor protein kinase that belongs to the TEC family kinases. It plays an important role in the B-cell receptor signaling pathway (BCR) and its pharmacological inhibition has been demonstrated as an effective strategy for the treatment of B-cell malignancies. LÄS MER