Avancerad sökning

Hittade 3 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Translational Aspects of Blood-Brain Barrier Transport and Brain Distribution of Drugs in Health and Disease

   Författare :Sofia Gustafsson; Margareta Hammarlund-Udenaes; Stina Syvänen; Irena Loryan; Danica Stanimirovic; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Blood-brain barrier; Neurovascular unit; Pharmacokinetics; Neurodegenerative disease; Drug transport; Brain tissue binding; Positron emission tomography; Brain regions; Farmaceutisk vetenskap; Pharmaceutical Science;

   Sammanfattning : A high unmet medical need in the area of CNS diseases coincides with high failure rates in CNS drug development. Efficient treatment of CNS disease is constrained by limited entrance of drugs into the brain owing to the blood-brain barrier (BBB), which separates brain from blood. LÄS MER

3. 2. A pharmacokinetic approach to intra-brain distribution with a focus on cyclic peptides

   Författare :Erik Melander; Margareta Hammarlund-Udenaes; Irena Loryan; Ulf Göransson; Xavier Declèves; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Farmakokinetik och läkemedelsterapi; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi; Pharmacokinetics and Drug Therapy;

   Sammanfattning : When designing treatments for disorders of the central nervous system (CNS) reaching the site of action is a major hurdle in the development process. Regardless if the target is extra- or intracellular, precise measurements to understand the distribution within the CNS are required. LÄS MER

4. 3. Advanced Mass Spectrometry Imaging in Neuropharmacology

   Författare :Theodosia Vallianatou; Per E. Andrén; Anna Nilsson; Mohammadreza Shariatgorji; Maria Karlgren; Irena Loryan; Nathalie Agar; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mass spectrometry imaging; neuropharmacology; blood brain barrier; drug-drug interactions; aging; tacrine;

   Sammanfattning : Mass spectrometry imaging (MSI) has emerged as a valuable approach for mapping multiple molecular species in sections of diverse tissues. It enables simultaneous detection of numerous compounds (from neurotransmitters to small proteins) in the brain at relatively high lateral resolution (>5 μm) on a routine basis. LÄS MER