Sökning: "Ionizing"

Visar resultat 21 - 25 av 188 avhandlingar innehållade ordet Ionizing.

  1. 21. Measurement of sensitivity to DNA damaging agents

    Författare :Sherin T Mathew; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; intrinsic sensitivity; DNA damage; ionizing radiation; cell division;

    Sammanfattning : There is a large inter-individual variation in intrinsic sensitivity in patients receiving treatment with DNA damaging agents. Cancer therapy exemplifies this problem where patients experience varying degree of normal tissue side effects in response to radiation or chemotherapy. LÄS MER

  3. 22. Replication Dynamics in the DNA Damage Response

    Författare :Petra Groth; Thomas Helleday; Geroge Iliakis; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; DNA damage; DNA replication; homologous recombination; DNA double strand-breaks; ionizing radiation; alkylating agents; NATURAL SCIENCES; NATURVETENSKAP; Genetics; Genetik; molekylärgenetik; Molecular Genetics;

    Sammanfattning : Faithful DNA replication is essential and the induction of replication stress may have profound effects on genomic integrity. This is demonstrated by the formation of DNA double strand breaks (DSBs), considered to be the most toxic DNA lesions, at stalled replication forks. LÄS MER

  4. 23. Short and long-term effects of exposure to low dose and low dose rate of gamma radiation : using in vitro and in vivo models

    Författare :Traimate Sangsuwan; Siamak Haghdoost; Eva Forssell-Aronsson; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Low dose; Low dose rate; High dose rate; Ionizing radiation; Adaptive response; Senescence; Premature senescence; Oxidative stress; Drosophila embryo; Mutation; DNA repair; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : Assessment of human health risks from exposure to ionizing radiation (IR) is mainly based on the extrapolation of results from epidemiological studies on populations exposed to relatively high doses and often at high dose rates (HDR). Risk estimates after exposure to low doses and in particular at low dose rates (LDR) remain controversial due to a lack of epidemiological evidence. LÄS MER

  5. 24. Radiation response in human cells : DNA damage formation, repair and signaling

    Författare :Ann-Sofie Gustafsson; Bo Stenerlöw; Andrzej Wojcik; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; DNA damage; DNA repair; DSB; NHEJ; DNA-PK; ionizing radiation; heat-labile sites; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap;

    Sammanfattning : Ionizing radiation induces a range of different DNA lesions. In terms of mutation frequency and mammalian cell survival, the most critical of these lesions is the DNA double-strand break (DSB). DSB left unrepaired or mis-repaired may result in chromosomal aberrations that can lead to permanent genetic changes or cell death. LÄS MER

  7. 25. Studies of DNA repair strategies in response to complex DNA damages

    Författare :Ainars Bajinskis; Mats Harms-Ringdahl; Bo Stenerlöw; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; ionizing radiation; complex DNA damage; indirect effect of radiation; dimethyl sulfoxide; molekylärgenetik; Molecular Genetics;

    Sammanfattning : The main aim of this thesis was to study the role of the indirect actions of γ-rays and α-particles on the complexity of primary DNA damages and the repair fidelity of major DNA repair pathways: non-homologous end joining (NHEJ), homologous recombination repair (HRR) and base excision repair (BER). The complexity of radiation-induced damages increases and the proximity between damages decreases with increasing LET due to formation of ionization clusters along the particle track. LÄS MER