Sökning: "Ionizing Radiation"

Visar resultat 16 - 20 av 166 avhandlingar innehållade orden Ionizing Radiation.

  1. 16. Regional differences in the response of neural stem cells and their microenvironment to ionizing radiation

    Författare :Nina Hellström; Göteborgs universitet; []
    Nyckelord :ionizing radiation; neurogenesis; neural stem cells; inflammation; microglia; stem cell niche; trophic support;

    Sammanfattning : Radiation therapy is one of the most effective tools for treating malignant tumors; however, cranial irradiation often results in intellectual impairment and cognitive deficits, such as impaired learning and memory. Ionizing radiation generates DNA damage, causing proliferative cells to undergo apoptosis. LÄS MER

  3. 17. Oxidized nucleotides as a predictor of radiation sensitivity

    Författare :Ali Pour Khavari; Siamak Haghdoost; Marie Öhman; Anders Nilsson; Bo Stenerlöw; Neus Visa; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; 8-oxo-dG; Radiation; Sensitivity; Oxidized; Nucleotides; ROS; NOS; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : The direct and indirect effects of IR can lead to DNA damage and activation of DNA repair. The indirect effects of ionizing radiation mediated by reactive oxygen species (ROS) which produced through radiolysis of water and if not taken care of by the antioxidant system, can also give rise to oxidative stress. LÄS MER

  4. 18. Micro/nanometric Scale Study of Energy Deposition and its Impact on the Biological Response for Ionizing Radiation : Brachytherapy radionuclides, proton and carbon ion beams

    Författare :Fernanda Villegas Navarro; Anders Ahnesjö; Carmen Villagrasa; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ionizing radiation; Monte Carlo track structure code; Microdosimetric spread; Energy deposition clustering; RBE; Medicinsk radiofysik; Medical Radiophysics;

    Sammanfattning : Research in radiotherapy for cancer treatment focuses on finding methods that can improve the compromise between tumour cell inactivation versus damage to the surrounding healthy tissue. As new radiation modalities such as proton therapy become accessible for everyday clinical practice, a better understanding of the variation in biological response of the tumour and healthy tissues would improve treatment planning to achieve optimal outcome. LÄS MER

  5. 19. Novel radiation targets in the endothelium and heart muscle

    Författare :Venkata Ramesh Yentrapalli; Siamak Haghdoost; William F. Morgan; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Ionizing radiation; Endothelial cells; Senescence; Cardiovascular disease; Proteomics; molekylärgenetik; Molecular Genetics;

    Sammanfattning : Worldwide, people are being exposed to natural and man-made sources of radiation. Epidemiological studies have shown an increased risk of vascular diseases in populations that have been exposed to ionizing radiation. Vascular endothelium is implicated as one of the targets for radiation leading to the development of cardiovascular diseases. LÄS MER

  7. 20. Induction of apoptosis in relation to chromatin structure and inhibition of replication by DNA damage from ionizing radiation

    Författare :Jesper Torudd; Mats Harms-Ringdahl; Mats Ljungman; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ionizing radiation; DNA-loop; replication fork; Toxicology; Toxikologi;

    Sammanfattning : The theme of this thesis has been chromatin organization ranging from methodological studies to involvement in apoptotic response. The aims have been: (i) to compare the information obtained by the AVTD method and comet assay concerning DNA-loop organization, (ii) to test the hypothesis that DNA-loop relaxation could be the triggering signal for induction of apoptosis in G0-lymphocytes, and (iii) to study the dose response for inhibition of the replication fork movement and pathways for the DNA repair process at the replication fork. LÄS MER