Sökning: "Ion homeostasis"

Visar resultat 6 - 10 av 52 avhandlingar innehållade orden Ion homeostasis.

1. 6. Modeling Biophysical Mechanisms underlying Cellular Homeostasis

   Författare :Padideh Kamali-Zare; Hjalmar Brismar; Charles Nicholson; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biological physics; Biologisk fysik;

   Sammanfattning : Cellular homeostasis is the effort of all living cells to maintain their intracellular content when facing physiological change(s) in the extracellular environment. To date, cellular homeostasis is known to be regulated mainly by time-consuming active mechanisms and via multiple signaling pathways within the cells. LÄS MER

3. 7. Applying the Pump and Leak Hypothesis. An experimental and theoretical investigation of the principles of ion regulation and excitability in the crustacean stretch receptor neuron

   Författare :Sten Theander; Människan i rörelse: hälsa och rehabilitering; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurology; neuropsychology; lobster; stretch receptor neuron; leak current; Q-current; K-Cl cotransporter; A-current; mathematical model; excitability; GABA channel; neurophysiology; ion regulation; neuropsykologi; Neurologi; neurofysiologi;

   Sammanfattning : An invertebrate nerve cell preparation, the lobster stretch receptor neuron, was investigated with respect to maintenance of its resting voltage, intracellular ion concentrations and excitability using voltage clamp technique and ion-selective microelectrodes. It was found that the resting voltage (-65 mV) of microelectrode impaled cells is caused by (a) a homogenous population of K+ channels which we denoted as leak channels (b) an electrogenic and voltage-dependent Na-K pump current and (c) an inward microelectrode-induced "impalement" current carried mainly by Na+. LÄS MER

4. 8. Mechanisms of Brain Damage Following Focal Cerebral Ischemia: Changes in Ion Homeostasis and the Importance of Free Radical Formation

   Författare :Gunilla Gidö; Sektion IV; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PBN; free radicals; potassium; extracellular calcium; neuronal damage; energy-depletion; hypoglycemia; Cerebral focal ischemia; spreading depression; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

   Sammanfattning : In this thesis mechanisms of neuronal damage were investigated in an experimental stroke model i.e focal ischemia. The influence of SD-induced calcium transients on neuronal damage were studied in animals with reduced energy supply. LÄS MER

5. 9. Elucidating the molecular basis of Na+/H+ exchange

   Författare :Pascal F. Meier; David Drew; Simon Newstead; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; membrane protein; secondary-active transporter; Solute Carrier Transporter; ion-exchange; sodium proton exchanger; potassium proton exchanger; protein structure; cryo-EM; regulation; biokemi; Biochemistry;

   Sammanfattning : Solute carrier (SLC) transporters are membrane transport proteins, which catalyse the movement of nutrients, ions, and drugs across cell membranes. Here, I will present our contribution to understanding the mechanism of the sodium/proton exchangers (NHE), belonging to the SLC9 family of membrane transporters. LÄS MER

7. 10. Energy Metabolic Stress Syndrome : Impact of Physical Activity of Different Intensity and Duration

   Författare :Stefan Branth; Leif Hambraeus; Gunnar Ronquist; Mats Stridsberg; Lennart Kaijser; Uppsala universitet; []
   Nyckelord :Medicine; energy; ATP; metabolism; nutrition; body-composition; physical-activity; stress; insulin-resistance; ion-pumps; intracellular swelling and -shrinkage; taurine; reactive oxygen species; Medicin;

   Sammanfattning : All living cell functions require an ongoing supply of energy derived from carbohydrates, lipids and proteins with their own pathways of breakdown. All of them end up in the oxidation of reduced coenzymes, yielding chemically-bound energy in the form of adenosine triphosphate (ATP). LÄS MER