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1. 1. New Approaches to Studies of Paracellular Drug Transport in Intestinal Epithelial Cell Monolayers

   Författare :Staffan Tavelin; Per Artursson; Staffan Tavelin; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; intestinal epithelium; tight junctions; cell culture; Galenisk farmaci; Pharmaceutics; Galenisk farmaci; galenisk farmaci; Pharmaceutics;

   Sammanfattning : Studies of intestinal drug permeability have traditionally been performed in the colon-derived Caco-2 cell model. However, the permeability of these cell monolayers resembles that of the colon rather than that of the small intestine, which is the major site of drug absorption following oral administration. LÄS MER

3. 2. Exploring Intestinal Ischemia : An experimental study

   Författare :Rolf Fröjse; Conny Arnerlöv; Ola Winsö; Stefan Lehtipalo; Eric Wahlberg; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; gastrointestinal tonometry; continuous; pig; pHi; intestinal ischemia; intestinal vascular bed; lactate; tissue oxygen tension; microdialysis; dopexamine; Kirurgi; Surgery; Kirurgi; Surgery; kirurgi;

   Sammanfattning : Background and aims: Unrecognized intestinal mucosal ischemia in severely ill patients may trigger development of multiple organ failure. Such ischemia can be evaluated by intraluminal tonometry reflecting mucosal PCO2 and intramucosal pH (pHi). LÄS MER

4. 3. Intestinal Mucosa Reconstitution and Protection: Impact of Luminal Factors

   Författare :Yilei Mao; Lund Kirurgi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Probiotics; Pectin; Oat; Methotrexate; Lactobacilli; Intestinal injury; Intestinal immunity; Intestinal barrier; Enterocolitis; Fiber; Radiation; Surgery; orthopaedics; traumatology; Kirurgi; ortopedi; traumatologi;

   Sammanfattning : The gastrointestinal mucosa is one of the most rapidly proliferating tissues in the body, and serves as a barrier to luminal bacteria and toxins. Enteral nutrition, luminal fiber and probiotics are of crucial importance for the integrity of this barrier. LÄS MER

5. 4. Membrane transport and the human small intestine : Relation to mucosal protection, intestinal anaphylaxis and nitric oxide

   Författare :Tina W. Knutson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; albumin; bicarbonate secretion; carbonic anhydrase; dopamine; duodenum; histamine; humans; hyaluronan; intestinal anaphylaxis; intestinal obstruction; jejunum; lidocaine; LOC-I-GUT; nitecapone; nitric oxide; potential difference; prostaglandins; segmental intestinal perfusion; Kirurgi; Surgery; Kirurgi; anestesiologi; Anaesthesiology;

   Sammanfattning : The tightly adherent monolayer of epithelial cells that line the luminal side of the intestine provides a dynamic and highly regulated barrier to the passive and active transport of ions, water and macromolecules. Cathecol-O-methyl transferase inhibition prevents tissue degradation of catecholaminesincluding dopamine and intracellular carbonic anhydrase activity is an important regulator of ion and water transport in the small intestine. LÄS MER

7. 5. Intestinal preservation for transplantation: translational approaches

   Författare :John M. Söfteland; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; intestinal transplantation; intestinal preservation; apoptosis; tight junction; luminal preservation;

   Sammanfattning : Background: Intestinal preservation injury (IPI) may result in various degrees of mucosal damage, which may later favor bacterial translocation, post-reperfusion syndrome, and upregulation of alloreactivity. Experimental evidence suggests that combining vascular perfusion and cold storage with luminal interventions using polyethylene glycol (PEG) solutions may mitigate the mucosal damage and extend the safe storage time. LÄS MER