Sökning: "Interleukin-13"

Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet Interleukin-13.

  1. 1. Effects of Interleukin-4 and Interleukin-13 on Bone

    Författare :Carl-Johan Silfverswärd; Olle Nilsson; Östen Ljunggren; Kenneth Jonsson; Li Felländer-Tsai; Uppsala universitet; []
    Nyckelord :Medicine; Bone; Osteoblasts; Interleukin-4; Interleukin-13; Knockout; Medicin;

    Sammanfattning : Cytokines play important roles in bone metabolism, participating in the complex interplay necessary for normal bone formation and turnover. The aim of the present thesis was to investigate the effects of two anti-inflammatory cytokines, interleukin-4 (IL-4) and interleukin-13 (IL-13) on bone. LÄS MER

  2. 2. Effects of inflammatory mediators on human osteoblasts

    Författare :Anders Frost; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; Kirurgi; Surgery; Kirurgi; Orthopaedics; ortopedi;

    Sammanfattning : Inflammatory mediators produced in or adjacent to bone have implications on bone and may induce both osteolysis and/or osteosclerosis. Inflammatory cytokines mediate these effects by acting either directly or indirectly on the bone cells. LÄS MER

  3. 3. Effects of Th-1 and Th-2 Cytokines and Reactive Oxygen Species on Normal Human Bronchial Epithelial Cells

    Författare :Caroline Kampf; Benjamin Gaston; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; ytokines; desmosomes; focal adhesions; free radicals; hypochlorous acid; nitric oxide; normal human bronchial epithelial cells; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Sammanfattning : Epithelial damage and shedding of the epithelium are common observations in many airway diseases such as asthma, Sjögren’s syndrome, chronic obstructive pulmonary disease and cystic fibrosis. The ability of the cells to attach to each other and/or to the matrix seems to be altered. LÄS MER

  4. 4. On the regulation of immune responses to dietary and self antigens

    Författare :Susanne Lindgren; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :Tolerance; regulatory T cells; self antigens; oral tolerance; dietary antigens; intestinal epithelial cells; exosomes; Staphylococcus aureus enterotoxin A;

    Sammanfattning : Regulatory mechanisms are necessary to avoid the misdirected aggressive immune responses responsible for the pathology seen in autoimmunity and allergy. Thymic-derived CD4+CD25+ regulatory T cells are indispensible for this regulation. We investigated if CD4+CD25+ Treg prevents auto-reactive responses in adult peripheral blood and cord blood. LÄS MER

  5. 5. Development of multi-cellular human lung models to study inflammatory mechanisms and cell-cell interactions

    Författare :Jie Ji; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Sammanfattning : It is well known that exposure to toxicants in the environment is associated with a wide range of health effects. The airway epithelium which forms the first line of defense, plays critical roles in the defence against inhaled particles, pathogens and toxic agents. LÄS MER