Sökning: "Interleukin-1"

Visar resultat 21 - 25 av 82 avhandlingar innehållade ordet Interleukin-1.

  1. 21. Neuroprotection in the Injured Spinal Cord : Novel Strategies using Immunomodulation, Stem cell Transplantation and Hyaluronic acid Hydrogel carriers

    Författare :Nikos Schizas; Nils Hailer; Elena Kozlova; Mikael Svensson; Uppsala universitet; []
    Nyckelord :Hyaluronic Acid-based hydrogel; motorneurons; microglial cells; Interleukin-1 Receptor Antagonist; Renshaw cells; excitotoxicity; neuroinflammation; Neural Crest Stem Cells; Medicinsk vetenskap; Medical Science;

    Sammanfattning : The overall aim of this thesis was to establish strategies to minimize secondary damage to the injured spinal cord. Secondary damage that follows spinal cord injury (SCI) involves inflammatory and excitotoxic pathways. LÄS MER

  3. 22. Testicular interleukin-1 alpha: Isolation, purification and and identification of a constitutively produced and secreted cytokine by the intact adult rat testis

    Författare :Katarina Gustafsson; Karolinska Institutet; []
    Nyckelord :Biomedical Sciences; Biomedicinsk vetenskap;

    Sammanfattning : .... LÄS MER

  4. 23. The prognostic significance of uPA, uPAR an d the cytokine IL-1-alpha in urinary bladder cancer

    Författare :Maria Seddighzadeh; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Urinary bladder cancer; urokinase; urokinase receptor; interleukin-1;

    Sammanfattning : Tumor invasion and metastasis are the major causes of cancer-related death. Proteases are important for the invasive and metastatic propensities of tumors. We have studied the mechanism underlying endogenous expression of the serine protease urokinase plasminogen activator (uPA) by human breast cancer cells. LÄS MER

  5. 24. Studies of cytokine mediated regulation of central nervous functions : role of prostaglandins

    Författare :Monica Ek; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :interleukin-1; prostaglandin E2; central nervous system; HPA axis; fever; vagus nerve;

    Sammanfattning : The communication between the immune system and the central nervous system (CNS) results in an array of centrally regulated illness responses, including fever and increased hypothalamus-pituitary-adrenal (HPA) axis activity. The mechanisms by which the immune system signals the brain across the blood-brain barrier have not been completely elucidated, but proinflammatory cytokines, like interleukin-1 (IL-1), are believed to act as important mediators. LÄS MER

  7. 25. Temporomandibular joint pain, hyperalgesia and allodynia in relation to interleukin-1ß and serotonin

    Författare :Per Alstergren; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Arthritis; Human; Hydroxocobalamin; Hyperalgesia; Inflammation; Interleukin-1; Pain; Plasma; Serotonin; Synovial fluid; Temporomandibular joint; Vitamin B12;

    Sammanfattning : This thesis had two main aims and comprises a methodological and a clinical part. The aims were to develop a temporomandibular joint (TMJ) synovial fluid (SF) sampling method that enables the determination of the true SF level of various substances and, by using the developed TMJ SF sampling method, investigate the hypothesis that circulating as well as SF content of interleukin-1ß (IL-1ß) and serotonin (5-HT) influence different TMJ pain entities and signs of tissue destruction in patients with TMJ inflammatory disorders. LÄS MER