Sökning: "Interleukin-1"
Visar resultat 11 - 15 av 82 avhandlingar innehållade ordet Interleukin-1.
11. Blocking interleukin-1 signalling in the brain-structural and functional outcomes
Sammanfattning : The aims of this thesis were to evaluate the consequences of blocking interleukin (IL)-1 signalling in the brain. The studies used a transgenic mouse model with brain-directed overexpression of the human soluble isoform of IL-1 receptor antagonist with the GFAP promoter (Tg hsIL-1ra). LÄS MER
12. The Interleukin-1 family of proteins in the brain and adrenal gland : regulation in response to bacterial LPS
Sammanfattning : Interleukin-1 (IL-1) is mediating diverse physiological conditions as inflammatory response, fever and sickness behaviour but also, via activation of the hypothalamus-pituitary-adrenal (HPA)-axis, the release of the anti-inflammatory adrenocorticoids. The neuroendocrine system as well as the central nervous system (CNS) is involved in the regulation of these conditions in the body. LÄS MER
13. Cytokines in the nervous system with emphasis on interleukin-1 receptor-mediated activity
Sammanfattning : Interleukin-1 (IL-1) is one of the most important pro-inflammatory cytokines and plays a pivotal role in the neuroinflammation associated with certain forms of neurodegeneration, such as epilepsy, cerebral ischemia, trauma, and Alzheimer's disease (AD). Also, it was suggested that IL-1 is involved in physiological processes, namely modulation of sleep, glucose and lipid metabolism, and neuroendocrine regulation, as well as modulation of learning and memory. LÄS MER
14. Regulation of the expression of IL-1 and related cytokines
Sammanfattning : .... LÄS MER
15. Oligodendrocyte pathology following Traumatic Brain Injury : Experimental and clinical studies
Sammanfattning : Traumatic brain injury (TBI) caused by traffic and fall accidents, sports-related injuries and violence commonly results in life-changing disabilities. Cognitive impairments following TBI may be due to disruption of axons, stretched by the acceleration/deceleration forces of the initial impact, and their surrounding myelin in neuronal networks. LÄS MER