Sökning: "Interindividual variability"

Visar resultat 1 - 5 av 39 avhandlingar innehållade orden Interindividual variability.

  1. 1. Interindividual Variability of Drug Transport Proteins : Focus on Intestinal Pgp (ABCB1) and BCRP (ABCG2)

    Författare :Gunilla Englund; Per Artursson; Håkan Melhus; Andreas Kindmark; Joseph W Polli; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; membrane transport proteins; ATP-Binding Cassette Transporters; P-glycoprotein; Breast Cancer Resistance Protein; Interindividual variability; Galenisk farmaci; Pharmaceutics; Galenisk farmaci;

    Sammanfattning : The appearance of adverse drug reactions is a common reason for hospitalization in Western countries. Research on underlying biological mechanisms for interindividual variability in drug response aims to better identify patients with exceptional genetic traits, disease conditions or risk of drug-drug interactions and thereby help to prevent adverse drug reactions. LÄS MER

  3. 2. Uncertainty, variability and environmental risk analysis

    Författare :Monika Filipsson; Tomas Öberg; Bo Bergbäck; Lars Rosén; Linnéuniversitetet; []
    Nyckelord :Contaminated land; exposure assessment; exposure factors; risk analysis; risk perception; uncertainty; variability; probabilistic risk assessment; NATURAL SCIENCES; NATURVETENSKAP; Miljövetenskap; Environmental Science;

    Sammanfattning : The negative effects of hazardous substances and possible measures that can be taken are evaluated in the environmental risk analysis process, consisting of risk assessment, risk communication and risk management. Uncertainty due to lack of knowledge and natural variability are always present in this process. LÄS MER

  4. 3. Pharmacogenetic Studies of Paclitaxel in Ovarian Cancer : focus on interindividual differences in pharmacodynamics and pharmacokinetics

    Författare :Henrik Green; Curt Peterson; Peter Söderkvist; Per Rosenberg; Håkan Melhus; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacogenetics; paclitaxel; LC MS; Taxol; ovarian cancer; pharmacokinetics; CYP2C8; CYP3A4; ABCB1; äggstockscancer; paklitaxel; Clinical pharmacology; Klinisk farmakologi;

    Sammanfattning : Ovarian cancer is one of the most common female cancer diseases in the world today and in Sweden more than 800 new cases are diagnosed every year. The standard treatment consists of chemotherapy with paclitaxel in combination with carboplatin after initial cytoreductive surgery. LÄS MER

  5. 4. Exposure assessment for the prevention of musculoskeletal disorders

    Författare :Istvan Balogh; Avdelningen för arbets- och miljömedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Yrkesmedicin; industrial medicine; Occupational health; heart rate; interindividual variation; index; arbetsmiljömedicin; job strain; Questionnaire; mechanical exposure;

    Sammanfattning : Work-related musculoskeletal disorders of shoulder/neck are a major and increasing problem. Beside the pain, they involve high cost for the employer and society. The total expenditure for the musculoskeletal disorders of the neck and upper limb have been estimated to 0.5-2. LÄS MER

  7. 5. Interindividual differences in xenobiotic-metabolising enzymes : the human genetic factor

    Författare :Roman A McLellan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The vast number of human xenobiotic-metabolising enzymes display interindividual variability that can alter the disposition of any compound metabolised by these enzymes, including environmental chemicals and many clinically used drugs. Both genetic and non-genetic factors affect the levels and activities of these enzymes. LÄS MER