Sökning: "Interferon regulatory factor 5"

Visar resultat 1 - 5 av 17 avhandlingar innehållade orden Interferon regulatory factor 5.

1. 1. The Genetics of Systemic Lupus Erythematosus : The Specificity of IRF5 to SLE

   Författare :MV Prasad Linga Reddy; Marta Alarcön Riquelme; Dan Holmberg; Uppsala universitet; []
   Nyckelord :Molecular genetics; Systemic lupus erythematosus; Interferon regulatory factor 5; Transmission-Disequilibrium Test; Family-based association test; Linkage Disequilibrium; Hardy-Weinberg equilibrium; Genetik;

   Sammanfattning : The breakdown of self-tolerance is the main driving force behind susceptibility to SLE. When this occurs, T and B cells are activated in an uncontrolled manner and produce autoantibodies against self fragmented DNA, RNA and sometimes other parts of the cell such as cardiolipin, phosphatidylserine, etc. LÄS MER

3. 2. Clinical and Experimental Studies in Primary Sjögren’s Syndrome and Systemic Lupus Erythematosus

   Författare :Gunnel Nordmark; Lars Rönnblom; Olle Kämpe; Ola Winqvist; Lennart Jacobsson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; Sjögren’s syndrome; SLE; α-fodrin; interferon-α; single nucleotide polymorphism; dehydroepiandrosterone; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin;

   Sammanfattning : Autoimmune mechanisms and genetic susceptibility contribute to the pathogenesis of primary Sjögren’s syndrome and SLE. These chronic systemic autoimmune diseases have many serological and clinical features in common and have an impact on daily life. LÄS MER

4. 3. Gene regulatory mechanisms in the oligodendrocyte lineage in development and disease

   Författare :Mandy Meijer; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Oligodendrocytes are the myelinating cells of the central nervous system (CNS). They contribute to the neuronal network through the insulation of neuronal axons, facilitating communication between neurons and providing metabolic support. LÄS MER

5. 4. Large-Scale Genotyping for Analysis of the Type I Interferon System in Autoimmune Diseases

   Författare :Snaevar Sigurdsson; Ann-Christine Syvänen; Timothy Behrens; Uppsala universitet; []
   Nyckelord :Molecular medicine; Minisequencing; SNP; Microarray; Polymorphism; Mitochondria; Systemic Lupus Erythematosus; Rheumatoid Arthritis; Association study; Type I interferon; Genotyping; Molekylärmedicin;

   Sammanfattning : Single nucleotide polymorphisms (SNPs) are the most common form of genetic variation. We developed a novel multiplexed method for SNP genotyping based on four-color fluorophore tag-microarray minisequencing. This method allows simultaneous genotyping of 80 samples and up to 200 SNPs in any allele combination. LÄS MER

7. 5. Immuno-regulatory dynamics of non-structural protein 1 of avian influenza A viruses : IFN-β, NF-κB and AP-1 perspectives

   Författare :Muhammad Munir; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
   Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

   Sammanfattning : The type I interferon (IFN-α/β) system represents the first line of defense against influenza A viruses, and is mainly mediated by the interferon regulatory factors 3/7 (IRF3/7), nuclear factor kappa B (NF-κB) and activator protein 1 (AP-1) transcription factors. Therefore, the non-structural protein 1 (NS1) of influenza A viruses has intrinsic abilities to disarm the host cell IFN system, and as a consequence is deeply connected to influenza virus pathogenicity and virulence. LÄS MER