Sökning: "Intercellular communication"

Visar resultat 21 - 25 av 44 avhandlingar innehållade orden Intercellular communication.

1. 21. Novel roles of ErbB3 receptor tyrosine kinase in vesicular trafficking

   Författare :Ana Rosa Saez-Ibañez; Ingvar Ferby; Carl-Henrik Heldin; Johanna Ivaska; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ErbB3; Integrin; GGA3; Rabaptin5; PKD; Ack1; endocytic recycling; exosome; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi;

   Sammanfattning : ErbB3 is a catalytically impaired receptor tyrosine kinase (RTK) from the EGFR family. Upon ligand binding, ErbB3 forms heterodimers with other members of the family and triggers phosphorylation cascades that promote crucial cellular functions as proliferation, differentiation and survival. LÄS MER

3. 22. Regulation of cellular plasticity and extracellular vesicle secretion in breast cancer

   Författare :Chrysoula Tsirigoti; Aristidis Moustakas; Carl-Henrik Heldin; Pierre Savagner; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cellular plasticity; extracellular vesicles; breast cancer; EMT; Molekylär medicin; Molecular Medicine; Molekylär cellbiologi; Molecular Cellbiology;

   Sammanfattning : Epithelial-to-mesenchymal transition (EMT) is a dynamic process controlling the transition of cells between epithelial and mesenchymal states in various physiological or pathological conditions. In cancer, EMT promotes cell dissemination and metastatic colonization, enriches tumors with stem cell populations and confers resistance to anticancer therapy. LÄS MER

4. 23. Physico-chemical characteristics and quantitative structure-activity relationships of PCBs

   Författare :Patrik Andersson; Stephen Safe; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; polychlorinated biphenyls; PCBs; physico-chemical properties; statistical design; multivariate; PCA; PLS; biomagnification; BMF; bioassay; CYP1A; SAR; QSAR; REPs; risk assessment; Chemistry; Kemi; Chemistry; Kemi;

   Sammanfattning : The polychlorinated biphenyls (PCBs) comprise a group of 209 congeners varying in the number of chlorine atoms and substitution patterns. These compounds tend to be biomagnified in foodwebs and have been shown to induce an array of effects in exposed organisms. LÄS MER

5. 24. MOLECULAR ASPECTS OF ENDOTHELIAL CELL FUNCTION AND HYPOXIA-DEPENDENT TUMOR ANGIOGENESIS

   Författare :Paulina Kucharzewska; Bröstcancer-genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hypoxia; hypoxia-inducible factor; angiogenesis; anti-angiogenic therapy; endothelial cell; polyamines; microRNA; extracellular membrane vesicles; exosomes; glioblastoma;

   Sammanfattning : Hypoxia, or deficient oxygen levels, is an inherent feature of rapidly expanding tumor tissue. In order to survive in the hostile, hypoxic environment and to restore the supply of oxygen and nutrients tumor cells activate a variety of adaptive mechanisms. Among them, hypoxia-induced angiogenesis, i.e. LÄS MER

7. 25. Plasticity in mice nociceptive spinal circuits -role of cell adhesion molecules

   Författare :Jonas Thelin; Neurofysiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Long term-potentiation; Cell adhesion molecule; Pain; Somatosensory imprinting; Medicin människa och djur ; Medicine human and vertebrates ; Nociceptive withdrawal reflex; Species differences; Central sensitisation; Mouse strains; Spinal cord;

   Sammanfattning : Introduction: To understand the function of the genes and their products in the pain system, studies will have to deal with complex issues related to intercellular communication, e.g. plasticity in neuronal networks. LÄS MER