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Visar resultat 1 - 5 av 395 avhandlingar som matchar ovanstående sökkriterier.
1. Insulin signalling in human adipocytes : mechanisms of insulin resistance in type 2 diabetes
Sammanfattning : Prevalensen av fetma ökar drastiskt i stora delar av världen och utgör en stor riskfaktor för att utveckla insulinresistens och typ 2 diabetes. Fettväven kan bli mycket stor om för mycket energi tas upp av kroppen. LÄS MER
2. Glucose and lipid metabolism in insulin resistance : an experimental study in fat cells
Sammanfattning : Type 2 diabetes is usually caused by a combination of pancreatic β-cell failure and insulin resistance in target tissues like liver, muscle and fat. Insulin resistance is characterised by an impaired effect of insulin to reduce hepatic glucose production and to promote glucose uptake in peripheral tissues. LÄS MER
3. Fat cell insulin resistance : an experimental study focusing on molecular mechanisms in type 2 diabetes
Sammanfattning : The aim of the present thesis was to further increase our understanding of mechanisms contributing to and maintaining cellular insulin resistance in type 2 diabetes (T2D). For this reason, the effects of high glucose and insulin levels on glucose transport capacity and insulin signaling, with emphasis on insulin receptor substrate 1 (IRS-1) were assessed in fat cells. LÄS MER
4. Regulation of intracellular signaling events that modulate insulin action
Sammanfattning : Insulin regulates several mechanisms of fundamental importance to the body involving glucose, fat andprotein metabolism. Insulin resistance in skeletal muscle, liver and adipose tissue promotes an increaseddemand for insulin secretion. LÄS MER
5. Myxine insulin : amino-acid sequence, three dimensional structure, biosynthesis, release, physiological role, receptor binding affinity, and biological activity
Sammanfattning : The Atlantic hagfish, Myxlne. glutinosa,is the most primitive vertebrate extant, and it diverged from the main vertebrate evolutionary chain some 500 mi 11 ion years ago. LÄS MER