Sökning: "Innate immunity"

Visar resultat 21 - 25 av 329 avhandlingar innehållade orden Innate immunity.

  1. 21. Macrophages in Crohn's Disease: lnnate immune cellular and molecular mechanisms driving intestinal inflammation and fibrosis

    Författare :Frida Gorreja; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; macrophages; inflammatory macrophages; tissue-resident macrophages; efferocytosis; innate immunity; myeloid cells; fibroblasts; fibrosis; inflammasomes; Crohn´s disease; inflammatory bowel diseases; digestive diseases; mucosa immunology; intestinal immunity; intestinal inflammation; serum systemic inflammation; microbiota; metabolites;

    Sammanfattning : Macrophages and their interactions with the lamina propria and luminal microenvi-ronment are crucial in the pathogenesis of Crohn´s disease (CD), a chronic inflamma-tory disease with a strong inflammatory innate immune involvement. Therefore, in-terpreting macrophage activity in the intestinal microenvironment may identify treatment targets beneficial for at least a subgroup of patients. LÄS MER

  3. 22. The impact of viral vaccines in immunosuppressed and at-risk individuals

    Författare :Anja Rosdahl; Torbjörn Norén; Helena Hervius Askling; Sara Cajander; Leonardus (Leo) Visser; Örebro universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Vaccine; Vaccine failure; Immunocompromised host; Hepatitis A; Tick borne encephalitis; SARS-CoV-2; Innate immunity; Adaptive immunity;

    Sammanfattning : Vaccines have saved millions of lives, but for some individuals with a defective immune system the protection may be uncertain. This thesis aims to assess the immune response following viral vaccines in immunocompromised patients and in other groups at-risk. LÄS MER

  4. 23. Signaling pathways in the activation and proliferation of Drosophila melanogaster blood cells

    Författare :Carl-Johan Zettervall; Marie Meister; Umeå universitet; []
    Nyckelord :innate immunity; cellular immunity; molecular signaling; molekylärbiologi; Molecular Biology;

    Sammanfattning : The larva of the fruit fly Drosophila melanogaster is an excellent model to study the molecular control of innate cellular immune responses. Cellular responses take place, and can be studied, following infestation of the wasp Leptopilina boulardi. This response includes proliferation and activation (differentiation) of the blood cells (hemocytes). LÄS MER

  5. 24. Rho-GTPases in Rheumatoid Arthritis

    Författare :Eric Malmhäll-Bah; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rho-GTPases; rheumatoid arthritis; innate immunity; adaptive immunity; RA treatment;

    Sammanfattning : The success of alleviating rheumatoid arthritis (RA) symptoms is complicated by both heterogeneity of the disease and lack of predictive markers to guide treatment options. Deregulated Rho-GTPases, a family of hydrolase enzymes catalyzing guanosine triphospate (GTP) to guanosine diphospate (GDP), have a detrimental role in many diseases including RA. LÄS MER

  7. 25. Exploring Monoclonal Antibody Action Against the Group A Streptococcal M Protein

    Författare :Sebastian Wrighton; Infektionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; group A streptococcus; Streptococcus pyogenes; fibronectin; phagocytosis; innate immunity; antibodies; adaptive immunity;

    Sammanfattning : Group A Streptococcus (GAS) is a significant human pathogen that has developed multipleimmune evasion mechanisms to counter the host immune response. One of these mechanisms involvesthe production of the M protein, which, amongst other things, acts as an anti-phagocytic factor and canbind host proteins. LÄS MER