Sökning: "Innate immune system"

Visar resultat 1 - 5 av 345 avhandlingar innehållade orden Innate immune system.

1. 1. The role and mechanism of ubiquitin system in innate immune regulation

   Författare :Swarupa Panda; Nelson O. Gekara; Fredrik Elgh; Anna Överby; Geert van Loo; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; The ubiquitin system; Deubiquitinase; MYSM1; Innate immune regulation Toll-like receptor; RIG-l like receptors; Cytoplasmic DNA receptors; NOD-like receptors; Francisella tularensis; Immune subversion; molekylärbiologi; Molecular Biology;

   Sammanfattning : Pattern-recognition receptors (PRRs) include the cell surface or endosomal membrane localized Toll-like receptors (TLRs) and the cytoplasmic PRRs such as RIG-I-like receptors (RLRs), NOD-like receptors (NLRs) and cytoplasmic DNA receptors (CDRs). Triggering of PRRs culminates in the transcriptional induction of pro-inflammatory cytokines and type I interferons (IFNs) that coordinate protection against pathogens but require tight control to avert inflammatory diseases. LÄS MER

3. 2. Pathogen-mediated selection in the immune system of rodents : Exploring selection targets, functional effects and trade-offs

   Författare :Mridula Nandakumar; Funktionell zoologi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; pathogen-mediated selection; bank voles; Myodes glareolus; immune system; balancing selection; immune response; rodents; positive selection; transcriptomics;

   Sammanfattning : Pathogens cause disease and play an important role in shaping evolution of the host immune system. They create pressure on host immunity to evolve in numerous ways, most commonly by increasing divergence between species (positive selection) or increasing polymorphisms within a population (balancing selection). LÄS MER

4. 3. Innate immune mechanisms of atherosclerosis

   Författare :Xintong Jiang; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Atherosclerosis is a multi-factorial immune mediated disease in arterial wall characterized by lipid driven inflammation through activation of the immune system. Chronic vascular inflammation is an important component that modulates atherosclerosis evolution and its complications. LÄS MER

5. 4. Effects of Complement Opsonization of HIV on Dendritic Cells : and Implications for the Immune Response

   Författare :Rada Ellegård; Marie Larsson; Jorma Hinkula; Johan D Söderholm; William Paxton; Linköpings universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; HIV; dendritic cells; complement; innate immune response; TLR signaling; T cell activation; NK cells; inflammation; antiviral response; immune evasion;

   Sammanfattning : Dendritic cells are key players during HIV pathogenesis, and shape both the immediate immune response at the site of infection as well as directing the adaptive immune response against the virus. HIV has developed a plethora of immune evasion mechanisms that hijack dendritic cell functions, suppressing their ability to mount an accurate immune response and exploiting them for efficient viral transfer to target T cells. LÄS MER

7. 5. Haemophilus influenzae adhesins and the innate immune response

   Författare :Elena Ronander; Malmö Klinisk mikrobiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; inflammation; Haemophilus influenzae; Haemophilus surface fibrils; complement; innate immune response; protein E; respiratory epithelium; adhesins;

   Sammanfattning : Haemophilus influenzae is a human specific Gram-negative respiratory tract pathogen. Encapsulated H. influenzae strains exist in six different serotypes a-f, of which type b (Hib) is the most virulent. Hib is protected by the polysaccharide capsule when invading the blood circulaton and may cause diseases such as meningitis and epiglottitis. LÄS MER