Sökning: "Inhalation technique"

Visar resultat 1 - 5 av 18 avhandlingar innehållade orden Inhalation technique.

1. 1. Pulmonary Drug Absorption : In vitro and in vivo investigations of drug absorption across the lung barrier and its relation to drug physicochemical properties

   Författare :Ann Tronde; Gerrit Borchard; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; lung; pulmonary; drug delivery; inhalation; drug transport; pharmacokinetics; absorption; bioavailability; drug metabolism; preclinical; rat; in vivo; isolated and perfused lung; Caco-2; nebulization catheter; aerosol; physicochemical; peptide; efflux; FARMACI; PHARMACY; FARMACI; Biopharmaceutics; biofarmaci;

   Sammanfattning : Although, pulmonary drug delivery is a well established means for targeting of drugs to the lungs for the treatment of respiratory diseases as well as for the systemic delivery of volatile anesthetic agents, drug absorption kinetics in the lung have not been subjected to extensive research. The main objective of this thesis was to investigate drug absorption characteristics of the lung barrier, using the isolated and perfused rat lung model and in vivo pharmacokinetic studies in rats. LÄS MER

3. 2. Modulation of Inflammatory Response in Surgical Trauma

   Författare :Andreas Kvarnström; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; inflammatory response; cytokines; complement activation; colorectal surgery; laparoscopy; inhalation anesthesia; intravenous anesthesia; autologous blood transfusion;

   Sammanfattning : Surgical trauma results in the activation of inflammatory cascade systems in the body. Excessive systemic inflammation can lead to organ dysfunction in one or several organs. LÄS MER

4. 3. Lung mechanics and airway inflammation in murine models of asthma

   Författare :Sofia Jonasson; Josephine Hjoberg; Hedenstierna Göran; Carl Persson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; allergic asthma; airway inflammation; murine models; lung mechanics; forced oscillation technique; airway reactivity; deep inhalations; oxidative stress; nitric oxide; glucocorticoids.; Clinical physiology; Klinisk fysiologi; klinisk fysiologi; Clinical Physiology;

   Sammanfattning : Allergic asthma is an inflammatory disease of the airways and is characterized by eosinophilic inflammation and increased airway reactivity. In the studies presented in this thesis, lung mechanics and measurements of airway reactivity were assessed in anaesthetized tracheostomized mice by using an animal ventilator (flexiVent®). LÄS MER

5. 4. Charting the human lung with inhaled nanoparticles : Development of AiDA - a new diagnostic technique for respiratory disease

   Författare :Jonas Jakobsson; NanoLund: Centre for Nanoscience; []
   Nyckelord :Aerosol; lung; lung deposition; respiratory tract; nanoparticles; ultrafine particles; airspace dimension assessment; AiDA; Chronic obstructive pulmonary disease; COPD; lung morphology;

   Sammanfattning : Changes to the smallest structures of the distal lung are often the first sign of severe respiratory disease, but to date methods to detect and quantify these changes are limited. Chronic obstructive pulmonary disease (COPD) is currently estimated to be the third most common cause of death worldwide, but is to a large extent under-diagnosed, especially at early stages. LÄS MER

7. 5. Large organic aerosols in a human exposure chamber : applications in occupational dermatology and lung medicine

   Författare :Lennart Lundgren; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Aerosol; bakery dust; bronchoalveolar lavage; chamber design; dermal exposure; exposure chamber; inhalation; large organic aerosols; mannequin; neutralizer; particle size; pinewood dust; skin;

   Sammanfattning : Exposure to large organic aerosol particles may cause respiratory and skin reactions. The use of human exposure chambers offers possibilities for experimental exposure challenges carried out with patients, in research and for investigations of the effects of exposure on the skin and in the respiratory tract. LÄS MER