Sökning: "Ingela Fritzson"

Hittade 1 avhandling innehållade orden Ingela Fritzson.

1. 1. Inhibitors of Human and Malaria Parasite Dihydroorotate Dehydrogenase

   Författare :Ingela Fritzson; Centrum för analys och syntes; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; DHODH; Synthesis; Inhibitors.; Dihydroorotate dehydrogenase;

   Sammanfattning : In the first part of the PhD work, small chemical entities (fragments) found to inhibit human dihydroorotate dehydrogenase (DHODH), were chemically optimized. As part of an ample program at Active Biotech to find new drugs against autoimmune diseases, expanded fragments were repeatedly designed, synthesized and evaluated in a human DHODH assay. LÄS MER