Sökning: "Induced fit"

Visar resultat 16 - 20 av 50 avhandlingar innehållade orden Induced fit.

1. 16. The interplay between Giardia intestinalis and host intestinal epithelial cells : A tale of immune activation and suppression

   Författare :Jana Grüttner; Staffan Svärd; Mikael E. Sellin; Steven Singer; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Giardia; diarrhea; RNAseq; proteomics; small intestinal epithelial cells; enteroids; organoids; protozoan; differentiation; immune response; host-parasite interaction; swimming; Biologi med inriktning mot mikrobiologi; Biology with specialization in Microbiology;

   Sammanfattning : Giardia intestinalis is a non-invasive, protozoan parasite causing the diarrheal disease giardiasis in a variety of mammals, including humans. The parasite has two main life cycle stages; disease-causing trophozoites and infectious cysts. Trophozoites colonize the host’s upper small intestine by attaching to intestinal epithelial cells (IECs). G. LÄS MER

3. 17. Plasticity Driven Damage and Void Growth

   Författare :Mattias Olsson; Kärnfysik; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Termisk teknik; termodynamik; Maskinteknik; hydraulik; vakuumteknik; vibrationer; akustik; Thermal engineering; applied thermodynamics; vibration and acoustic engineering; vacuum technology; hydraulics; void growth; Mechanical engineering; damage evolution; elasto-plasticity; thermodynamics;

   Sammanfattning : Plasticity induced damage evolution is considered using a thermodynamical approach. Different postulates on how to include the effects of damage in the constitutive equations have been studied. The results reveal that a mapping, similar to that of the stress, of both the kinematic and isotropic hardening variables is to be preferred. LÄS MER

4. 18. Electrophysiology-based investigations of G protein-coupled receptor pharmacology

   Författare :Richard Ågren; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : G protein-coupled receptors (GPCRs) constitute targets for ~34% of approved drugs. The muscarinic acetylcholine M2 receptor (M2R) activates G protein-coupled receptor inward rectifying potassium (GIRK) channels in the central nervous system and heart. Membrane potential modulates agonist potency at several GPCRs. LÄS MER

5. 19. Integrative modeling of intratumoral heterogeneity, plasticity and regulation in nervous system cancers

   Författare :Ida Larsson; Sven Nelander; Fredrik Swartling; Patrik Johansson; Itay Tirosh; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Nervous system cancer; Glioblastoma; Heterogeneity; Plasticity; Mathematical modeling; Oncology; Onkologi;

   Sammanfattning : The adult brain tumor glioblastoma (GBM) is characterized by short survival and a lack of efficient treatments. Median survival is 15 months from time of diagnosis and the 5-year survival rate is only 7 %. LÄS MER

7. 20. Computational Studies of Structures and Binding Properties of Protein-Ligand Complexes

   Författare :Xu Wang; Yaoquan Tu; Lennart Nilsson; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Teoretisk kemi och biologi; Theoretical Chemistry and Biology;

   Sammanfattning : Proteins are dynamic structural entities that are involved in many biophysical processes through molecular interactions with their ligands. Protein-ligand interactions are of fundamental importance for computer-aided drug discovery. LÄS MER