Sökning: "In vivo reprogramming"

Visar resultat 6 - 10 av 32 avhandlingar innehållade orden In vivo reprogramming.

  1. 6. Regulatory properties of dendritic cells and B cells in adaptive immunity

    Författare :Bengt Johansson Lindbom; Adaptivt immunförsvar; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; serology; transplantation; Immunologi; serologi; Immunology; Cellular differentiation; Cytokines; Dendritic cells; B lymphocytes; T lymphocytes;

    Sammanfattning : This thesis is based upon four original papers in which human dendritic cells (DCs) and B cells have been analyzed in terms of how they influence the character of adaptive immune responses. DCs isolated from human tonsils were found to possess a capacity to directly regulate proliferation, isotype switching, and antibody production in B cells. LÄS MER

  3. 7. Neural Stem Cells - interaction with the brain and prospects for cell replacement therapy for Stroke

    Författare :Emanuela Monni; Neural stamcellsbiologi och terapi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neural stem cells; human; fetus; cortex; striatum; stroke; transplantation; inflammation; fusion; reprogramming; chimera; heterokaryon;

    Sammanfattning : Stroke is an acute neurological condition and the leading cause of disability in adult humans. Treatments for efficient recovery are not available. The most common form of stroke results from the occlusion of the middle cerebral artery, which causes loss of brain parenchyma and many types of neurons as well as astrocytes and oligodendrocytes. LÄS MER

  4. 8. Mechanisms Underlying the Specification of Definitive Hematopoiesis

    Författare :Rita Alves; Avdelningen för molekylärmedicin och genterapi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; GATA2; mitotic bookmarking; HSC; transcription factors; reprogramming;

    Sammanfattning : Hematopoietic stem cells (HSCs) maintain blood through self-renewal and differentiation. Although HSC transplantation is the only cure for various blood disorders, generating and maintaining HSCs in vitro remains challenging, partly due to a limited understanding of the cellular and molecular mechanisms underlying human HSC ontogeny. LÄS MER

  5. 9. Deciphering microglia plasticity in glioma

    Författare :Dalel Saidi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Microglia are the innate immune cells of the brain. One of the main characteristics of microglia is its extremely plasticity, which is necessary for them to deal with changing circumstances. Activation of microglia can contribute to contrasting effects by either proinflammatory, anti-inflammatory, or tumor-supportive phenotypes. LÄS MER

  7. 10. Impact of targeting MYC in metabolic reprogramming and differentiation of cancer

    Författare :Lourdes Sainero Alcolado; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Alterations in several metabolic pathways due to increased energy and biomass demand, as consequence of the uncontrolled proliferation of cancer cells, is known as metabolic reprogramming. Mutations in tumor suppressor genes and oncogenes that initiate cancer development, are responsible directly and indirectly of the changes in major cellular energy production processes, including glycolysis, glutaminolysis, and lipid metabolism. LÄS MER