Sökning: "In vivo reprogramming"

Visar resultat 11 - 15 av 32 avhandlingar innehållade orden In vivo reprogramming.

  1. 11. Coiled coil cytoskeleton in cell architecture and osmotic stress response in Streptomyces

    Författare :Katsuya Fuchino; Molekylär cellbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Coiled coil protein; Streptomyces coelicolor; polar growth; osmotic-stress response; turgor;

    Sammanfattning : Coiled coil proteins emerge as important determinants of bacterial cellular organization. Several such proteins display properties characteristic to metazoan intermediate filament (IF) proteins, and are therefore designated bacterial IF-like proteins. LÄS MER

  3. 12. Altered cell metabolism and migration in nasopharyngeal carcinoma

    Författare :Shixing Zheng; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Nasopharyngeal carcinoma (NPC) is a subtype of head and neck cancer, originating from the nasopharynx. The etiology of NPC is considered a complex interaction between Epstein–Barr virus (EBV) infection, genetic susceptibility, environmental factors, and lifestyle factors. NPC has the highest metastasis rate among all head and neck cancers. LÄS MER

  4. 13. The role of Notch signaling in cancer and metastasis

    Författare :Anders P Mutvei; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The Notch signaling pathway is an evolutionary conserved cell-to-cell communication pathway that regulates many important aspects in the development and tissue homeostasis of multicellular animals. It operates in a wide range of cellular contexts and dysregulated Notch signaling has been linked to a number of diseases, including cancer. LÄS MER

  5. 14. Direct Conversion of Human Fibroblasts to Induced Neurons

    Författare :Ulrich Pfisterer; Utvecklings- och regenerativ neurobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cellular Reprogramming; Direct Conversion; Human Induced Neurons; Dopaminergic; Cell Replacement Therapy; Lentiviral Vectors;

    Sammanfattning : During direct cellular reprogramming, forced expression of key transcription factors (TFs) directly converts one terminally differentiated cell type into that of another fate, exemplified in this theses by the conversion of fibroblasts into functional induced neurons (iNs). Direct conversion of mouse fibroblasts to functional neurons was established in 2010, and the starting point of my doctoral thesis was the aim to transfer iN-technology to human cells and to explore the potential of this technique in regards to generate subtype-specific neurons as well as to use these cells for transplantation studies. LÄS MER

  7. 15. Exploring Direct Conversion of Human Glia into Therapeutic Neurons

    Författare :Jessica Giacomoni; Utvecklings- och regenerativ neurobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human embryonic stem cells; glial progenitor cells; neuronal reprogramming; induced neurons; spheroids; brain slice cultures; neurodegenerative disorders;

    Sammanfattning : Direct neuronal reprogramming of a somatic cell into therapeutic neurons, without a transient pluripotent state, provides new promise for the large number of individuals afflicted by neurodegenerative diseases or brain injury. This approach could be potentially applied directly in the brain by targeting resident cells as a source of new neurons. LÄS MER