Sökning: "Imprinting control region"

Visar resultat 1 - 5 av 16 avhandlingar innehållade orden Imprinting control region.

  1. 1. Epigenetic Control of Mammalian Development : Studies on an imprinting control region

    Författare :Liang Liu; Pärt Peterson; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; Epigenetic; Genomic imprinting; DNA methylation; Igf2; H19; Insulator; CTCF; Imprinting control region; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi; zoologisk utvecklingsbiologi; Animal Development;

    Sammanfattning : A subset of autosomal genes is preferentially or exclusively expressed from one of the parental alleles. This phenomenon, termed genomic imprinting, is highlighted by the neighboring Igf2 and H19 genes, which are monoallelically expressed on opposite parental chromosomes. These features are governed by a 2. LÄS MER

  3. 2. Long-range Control of Gene Expression by Imprinting Control Regions During Development and Neoplasia

    Författare :Noopur Thakur; Chandrasekhar Kanduri; Thomas Ekstrom; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Genomic imprinting; Imprinting control region; Antisense RNA; de novo methylation; Molekylärbiologi; Molecular biology; Molekylärbiologi;

    Sammanfattning : Genomic imprinting is an epigenetic phenomenon by which a subset of genes is expressed in a parent of origin specific manner. Most of the imprinted genes are located in clusters. Genetic evidences suggest that genes in imprinted clusters are regulated by Imprinting Control Regions (ICRs). LÄS MER

  4. 3. Epigenetic Regulation and Reprogramming of the H19 Imprinting Control Region

    Författare :Piero Mariano; Rolf Ohlsson; Karl Ekwall; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; Imprinting; chromatin; H19; Igf2; CTCF; Insulator; methylation; Boris; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi;

    Sammanfattning : The development of a new individual from the fertilized oocyte can ultimately be seen as the consequence of the establishment and maintenance of specific patterns of gene expression. Although regulation of gene activity occurs at different levels, cellular specialization and differentiation are the results of developmental cues that essentially take place at the transcriptional level. LÄS MER

  5. 4. The Functional Significance and Chromatin Organisation of the Imprinting Control Regions of the H19 and Kcnq1 Genes

    Författare :Meena Kanduri; Rolf Ohlsson; Karl Ekwall; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular genetics; DNA methylation; Imprinting control region; Chromatin; Insulator; Nucleosome positioning; Genetik; Genetics; Genetik;

    Sammanfattning : Genomic imprinting is a phenomenon through which a subset of genes are epigenetically marked during gemtogenisis. This mark is maintained in the soma to often manifest parent of origin-specific monoalleleic expresson patterns. LÄS MER

  7. 5. Epigenetic Regulation of Genomic Imprinting and Higher Order Chromatin Conformation

    Författare :Gholamreza Tavoosidana; Rolf Ohlsson; Job Dekker; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; Epigenetic; Imprinting; Chromatin; CTCF; H19 ICR; 4C; Utvecklingsbiologi; Biology; Biologi;

    Sammanfattning : The genetic information encoded by the DNA sequence, can be expressed in different ways. Genomic imprinting is an epigenetic phenomenon that results in monoallelic expression of imprinted genes in a parent of origin-dependent manner. Imprinted genes are frequently found in clusters and can share common regulatory elements. LÄS MER