Sökning: "Immunologi transplantation serologi transplantation serology Immunology B cells Differentiation"
Visar resultat 1 - 5 av 11 avhandlingar innehållade orden Immunologi transplantation serologi transplantation serology Immunology B cells Differentiation.
1. Studies of molecular events during peripheral B cell differentiation
Sammanfattning : This thesis focuses on molecular changes occuring during terminal B cell differentiation as well as on somatic hypermutation and the generation and maintenance of B cell memory. During T cell dependent immune responses the average affinity for the eliciting antigen increases with time. LÄS MER
2. Regulatory properties of dendritic cells and B cells in adaptive immunity
Sammanfattning : This thesis is based upon four original papers in which human dendritic cells (DCs) and B cells have been analyzed in terms of how they influence the character of adaptive immune responses. DCs isolated from human tonsils were found to possess a capacity to directly regulate proliferation, isotype switching, and antibody production in B cells. LÄS MER
3. Gene regulation by Early B-cell Factor (EBF)
Sammanfattning : In this study we aimed at defining genes that are controlled by Early B-cell Factor (EBF), that could explain the severe block in B-cell development observed in EBF-/- mice. The fact that EBF appears to be important for the transcriptional control of genes encoding proteins in the pre-B and B-cell receptor complex implied to us that EBF could be a common regulator of other components in the pre-B and B-cell receptor. LÄS MER
4. Signalling mechanisms in B cell differentiation: Studies on specific human immune response in vitro
Sammanfattning : We need to understand the major signalling events in human B cell differentiation in order to be able to regulate the generation of human antigen specific antibodies. This study has focused on the signalling mechanisms involved in generation of germinal centre reaction and secretion of specific antibodies by human B cells, using different in vitro immunisation technologies. LÄS MER
5. Regulation of immunoglobulin transcription
Sammanfattning : Each Ig V-region has its own upstream promoter and the promoter of a mature Ig gene is thereby selected during the V(D)J recombination process. Upon comparison, it is evident that only one transcription factor binding site, the octamer, is preserved within all promoters. LÄS MER