Sökning: "Immunodeficiency state"

Visar resultat 6 - 10 av 11 avhandlingar innehållade orden Immunodeficiency state.

1. 6. Tec family kinases : transcriptional and posttranslational regulation

   Författare :Liang Yu; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Tec family tyrosine kinases consist of five members: Btk, Itk, Tec, Rlk/Txk and Bmx. These kinases are highly expressed in hematopoietic cells, including B cells, T cells and mast cells. LÄS MER

3. 7. Towards ribozyme-mediated gene therapy of HIV-1 infections

   Författare :Graham Hotchkiss; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Ribozymes; HIV-1; Telomere length; HAART; Gene Therapy;

   Sammanfattning : HIV-1 is the causative agent in AIDS, the world's fourth most frequent cause of death. HIV is a retrovirus that primarily infects macrophages and T helper cells - required for a proper immune response. LÄS MER

4. 8. Immune regulation during pulmonary TB and during M. tuberculosis/HIV-1 co-infection

   Författare :Chaniya Leepiyasakulchai; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Individually, tuberculosis (TB) and acquired immunodeficiency syndrome (AIDS) pose major global health problems and together, they form a deadly liaison. Preventive vaccines for any of the diseases are not yet available. LÄS MER

5. 9. Expression and function of the small immune adaptor protein SAP

   Författare :Noemi Nagy; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :XLP; SAP; EBV; BL; lymphocytes; lymphoma; p53; apoptosis; AICD;

   Sammanfattning : The Epstein-Barr virus (EBV) carrier state is widespread in humans. Primary infection can cause infectious mononucleosis (IM) that presents with variable clinical severity, but almost always subsides. For 50% of boys with a rare hereditary immunodeficiency, X-linked lymphoproliferative disease (XLP), primary infection with E13V has a fatal course. LÄS MER

7. 10. HIV-1 reverse transcriptase as a target in the development of specific enzyme inhibitors

   Författare :Hong Zhang; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Human immunodeficiency virus type I (HIV-I), which causes the acquired immunodeficiency syndrome (AIDS), begins its intracellular infection life cycle with reverse transcription of its plus-strand RNA genome into a double-stranded proviral DNA intermediate which is integrated into the host chromosome inducing a persistent infection. A virally encoded enzyme, reverse transcriptase (RT), carries out the reverse transcription process by performing all three enzymatic activities, i. LÄS MER