Sökning: "Immediate-early gene"

Visar resultat 1 - 5 av 39 avhandlingar innehållade orden Immediate-early gene.

1. 1. Effects of ethanol on the expression of immediate-early genes in nerve cells

   Författare :Wei-Qun Ding; Institutionen för laboratoriemedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuroadaptation; the central nervous system; AP-1; junD; junB; c-jun; fosB; c-fos; neuroblastoma SH-SY5Y; ethanol; immediate-early genes; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

   Sammanfattning : Immediate-early genes of the fos and jun families encode proteins that dimerize to form a complex of activator protein 1 and regulate the expression of a number of genes in the nervous system. Ethanol has previously been shown to induce alterations in expression of fos and jun genes in the brain. LÄS MER

3. 2. Molecular Etiology of Graves’ Disease and Associated Ophthalmopathy

   Författare :Tereza Planck; diabetes och endokrinologi Genomik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; association study; Graves’ disease; Graves’ ophthalmopathy; immediate early genes; inflammation; adipogenesis; thyrostimulin; BTG2; CYR61; COX2; ZFP36; gene expression; SCD; SNP;

   Sammanfattning : Graves' disease (GD) is a complex autoimmune disorder characterized by hyperthyroidism and diffuse goitre. 25-50% of the patients with GD develop eye symptoms, Graves' ophthalmopathy (GO). The overall aim of this thesis was to explore the molecular etiology of GD and GO. LÄS MER

4. 3. Methodological studies of eicosanoid enzyme gene expression in vascular endothelium exposed to biomechanical stress

   Författare :Roya Doroudi; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; prostanoids; endothelium; quantitative RT-PCR; perfusion model; shear stress; intraluminal pressure; immediate-early genes;

   Sammanfattning : Prostaglandins are the major eicosanoids synthesized by vascular endothelial cells, and the vasculature is an important target organ for their bioactive metabolites. In vitro studies have shown that biomechanical forces are important regulators of vascular expression of prostanoid enzymes and release of metabolites. LÄS MER

5. 4. Transcriptional dysregulation in L-DOPA-induced dyskinesia

   Författare :Malin Andersson; Neurobiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Clinical genetics; neurofysiologi; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; CREB; jun; fos; immediate early genes; prodynorphin; striatal plasticity; Parkinson s disease; dyskinesia; Klinisk genetik;

   Sammanfattning : This study explores the role of transcriptional regulation important in the development of L-DOPA-induced dyskinesia in a rat model of Parkinson’s disease. In patients with Parkinson’s disease, dyskinesia is one of the most difficult complications of the DA-replacement therapy by L-DOPA. LÄS MER

7. 5. Alcohol and gene expression in nerve cells with emphasis on transcription factor AP-1

   Författare :Ulrik Fried; Institutionen för laboratoriemedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nerve cells; SH-SY5Y; muscarinic receptors; MAPKs; PKC; gene expression; jun; Activating Protein-1; Alcohol; ethanol; CRABP-I; Clinical chemistry; Klinisk kemi;

   Sammanfattning : Alcohol induces profound effects on the function of the nerve cells in the nervous system. Alterations in gene expression is an important way by which these effects could be induced and sustained. Activating Protein-1 (AP-1) is a dimeric transcription factor constituted of proteins from the fos and jun immediate-early gene families. LÄS MER