Sökning: "Il-1β"

Visar resultat 16 - 20 av 141 avhandlingar innehållade ordet Il-1β.

  1. 16. Cytokine regulation of pancreatic -cell function with special reference to the pathogenesis of type 1 diabetes

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Johnny Sternesjö; [1999]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Diabetes; pancreatic islets; insulin secretion; cytokines; nitric oxide; streptozotocin; NOD mice; proteasome; nuclear factor-kappaB; Cellbiologi; MEDICINE Morphology; cell biology; pathology Cell biology; MEDICIN Morfologi; cellbiologi; patologi Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Sammanfattning : Cytokines produced by inflammatory cells have been implicated in the pathogenesis of type 1 diabetes. The overall aim of the present work was to test how different cytokines, supposed to be present in the insulitic lesion, could influence the function of islets of Langerhans. LÄS MER

  2. 17. Mycobacterium tuberculosis and the human macrophage shifting the balance through inflammasome activation

    Detta är en avhandling från Linköping : Linköping University Electronic Press

    Författare :Daniel Eklund; Maria Lerm; Olle Stendahl; Eva Särndahl; Norbert Reiling; [2013]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Mycobacterium tuberculosis is a very successful pathogen and tuberculosis constitutes a major threat to global health worldwide. The World Health Organization (WHO) estimates that almost nine million new cases and 1. LÄS MER

  3. 18. Cytokine-induced beta-cell apoptosis and its regulation by SOCS-1 and imidazoline compounds

    Detta är en avhandling från Stockholm : Karolinska Institutet, Dept of Molecular Medicine and Surgery

    Författare :Irina Zaitseva; Karolinska Institutet.; Karolinska Institutet.; [2014]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : A selective destruction of pancreatic β-cells as a consequence of inflammation in the islets of Langerhans is a feature of type 1 diabetes. Pro-inflammatory cytokines secreted by T lymphocytes and macrophages infiltrating the pancreatic islets participate in the development of this autoimmune disease by acting directly on the β-cell. LÄS MER

  4. 19. Hormonal regulation of immune modulators in human breast tissue

    Detta är en avhandling från Stockholm : Karolinska Institutet, Dept of Molecular Medicine and Surgery

    Författare :Vivian Morad; Charlotta Dabrosin; Christina Ekerfelt; Malin Sund; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Breast cancer is the most common form of cancer and the second leading cause of malignancy-associated death in women worldwide. Estrogens are the main sex hormones in women. LÄS MER

  5. 20. Regulation of cytokine-induced nitric oxide production in insulin-producing cells

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Malin Flodström; [1998]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Diabetes; pancreatic islets; insulin-producing cells; cytokines; nitric oxide; inducible nitric oxide synthase; nuclear factor-kappaB; interferon regulatory factor-1; arginine; citrulline; argininosuccinate synthetase; insulin release; Cellbiologi; MEDICINE Morphology; cell biology; pathology Cell biology; MEDICIN Morfologi; cellbiologi; patologi Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Sammanfattning : Cytokine-induced expression of the inducible form of nitric oxide synthase (iNOS) and production of nitric oxide (NO) may contribute to pancreatic β-cell damage during the development of type 1 diabetes. iNOS catalyses the conversion of arginine into citrulline and NO, a reaction regulated by the amount of expressed iNOS enzyme and by the cellular availability of arginine. LÄS MER