Sökning: "Il-1β"
Visar resultat 11 - 15 av 165 avhandlingar innehållade ordet Il-1β.
11. Regulation of inflammasomes by host- and pathogen-derived factors
Sammanfattning : The term inflammasome was first coined in 2002 and describes an intracellular multiprotein complex mediating inflammation by inducing the release of pro-inflammatory cytokines (IL-1β and IL-18) and a lytic form of cell death called pyroptosis. Since then, an impressive amount of research has revealed many details about the mechanisms of inflammasome activation as well as the functional relevance of inflammasome activation in different contexts. LÄS MER
12. Apnea and infection in neonates : mediatory role of interleukin-1Beta and prostaglandin E2
Sammanfattning : The breathing pattern of infants, particularly preterm infants, is often irregular or periodic and is frequently interrupted by apnea. The latter represents a major concern in haematology, yet much remains unknown about its incidence, appearance, and pathophysiology. LÄS MER
13. Genetic Variations in the NLRP3 Inflammasome : Susceptibility Factor for Chronic Inflammation
Sammanfattning : NLRP3 has been recognized as one of the key components of innate immunity. Upon activation, NLRP3 forms a multiprotein complex called as the ‘inflammasome’ which leads to the activation of pro-inflammatory caspase-1 which subsequently results in the formation of Interleukin (IL)-1β and IL-18. LÄS MER
14. Innate immunity in diabetes mellitus. Complement components C4BP and C3 promote survival of β cells under metabolic challenges
Sammanfattning : The Complement system is a main effector mechanism of the innate immune system, acting to enhance clearance of pathogens, but also aids removal of biological debris from the body, including immunocomplexes, apoptotic/necrotic cells and protein aggregates. Complement regulators serve to prevent excessive inflammation and their interaction with the same materials targeted by the complement system results in ‘silent’ cleaning of wastes. LÄS MER
15. Genetic variations in the NALP3 inflammasome: a susceptibility factor for inflammatory diseases
Sammanfattning : Innate immunity has received impressive attention in the past decade owing to the discovery of the Toll like receptors (TLRs) and the NOD-like receptors (NLRs). While the TLRs specialize in fighting microbes at the cell surface, the NLRs complement by detecting and responding to intracellular microbes. LÄS MER