Sökning: "IgA ligand"

Visar resultat 1 - 5 av 10 avhandlingar innehållade orden IgA ligand.

  1. 1. Studies on streptococcal M proteins. Interactions with IgA and human complement regulators

    Författare :Eskil Johnsson; Institutionen för laboratoriemedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Microbiology; antigenic variation; factor H; C4b-binding protein; Fc-receptor; IgA; Streptococcus pyogenes; M protein; mykologi; virologi; bakteriologi; Mikrobiologi; virology; mycology; bacteriology;

    Sammanfattning : The human pathogenic bacterium Streptococcus pyogenes (group A Streptococcus) expresses several different virulence factors. Of these, the M protein is regarded as one of the most important, because it confers resistance to phagocytosis, allowing the bacterium to multiply in blood. LÄS MER

  3. 2. Affibody ligands in immunotechnology applications

    Författare :Jenny Rönnmark; KTH; []
    Nyckelord :phage display; combinatorial; affinity; IgA ligand; immunohistochemistry; affibody-fusions;

    Sammanfattning : This thesis describes the development and use ofnon-immunoglobulin affinity proteins denoted affibodies asalternatives to antibodies in different immunotechnologyapplications. A 58 aa IgG Fc binding three-helix bundle domainZ, derived from staphylococcal protein A has been used asframework for library constructions, in which the face of themolecule involved in the native binding activity has beenengineered by combinatorial protein engineering. LÄS MER

  4. 3. Fluorescence-based ligand assays for protein detection using affibody affinity proteins

    Författare :Björn Renberg; Amelie Eriksson Karlström; Per-Åke Nygren; Jörg Hoheisel; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Affibody molecules; biosensors; FRET; immobilisation; solid-phase synthesis; protein microarrays; Biochemistry; Biokemi;

    Sammanfattning : The detection and quantification of biomolecules, and proteins in particular, are of great interest since these molecules are of fundamental importance to our well-being. Body fluids, as for instance human blood, are well suited for sampling of protein levels. LÄS MER

  5. 4. Deciphering Binding Patterns of Therapeutic Antibodies with Immune Cells : From Method Development to Application

    Författare :Sina Bondza; Jos Buijs; Marika Nestor; Mark Cragg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; affinity; binding kinetics; CD20; cell-based assay; immunology; receptor-ligand interaction; therapeutic antibody; Immunologi; Immunology; Medical Cell Biology; Medicinsk cellbiologi;

    Sammanfattning : Reversible binding, for example between signaling molecules and receptors on the cell surface, is one of the main means to communicate information in cellular systems. Knowledge about how molecules interact is crucial for both understanding biological function and for therapeutic intervention. LÄS MER

  7. 5. Cat allergy : diagnosis and characterization of important allergens

    Författare :Justus Adédoyin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Allergy affects about 25% of the population. Allergic diseases are manifested in many ways, from mild rhinitis to life-threatening anaphylaxis. Globally, more than 15% of children and adults are allergic to pets. The focus of this thesis is important cat allergens. LÄS MER