Sökning: "IMD pathway"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden IMD pathway.

  1. 1. Peptidoglycan recognition proteins in Drosophila melanogaster

    Författare :Thomas Werner; Dan Hultmark; Bruno Lemaitre; Umeå universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Drosophila; PGRP; peptidoglycan; pattern recognition; imd; Relish; isoform; RNAi; mbn-2; Molekylärbiologi; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : The fruit fly Drosophila melanogaster is an excellent model organism to study the innate immune response, because insects and mammals share conserved features regarding the recognition and destruction of microorganisms and Drosophila is easily accessible to genetic manipulation. In my present study, I identified a new family of pattern recognition molecules for bacterial peptidoglycan in Drosophila, the Peptidoglycan Recognition Proteins (PGRP). LÄS MER

  2. 2. Peptidoglycan Recognition Proteins : Major Regulators of Drosophila Immunity

    Författare :Peter Mellroth; Håkan Steiner; Julien Royet; Stockholms universitet; []
    Nyckelord :AGRICULTURAL SCIENCES; LANTBRUKSVETENSKAPER; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; Innate immunity; peptidoglycan recognition protein; PGRP; Toll; Imd; Drosophila immunity; Microbiology and immunology; Mikrobiologi och immunologi;

    Sammanfattning : All eukaryotic organisms have an innate immune system characterized by germ-line encoded receptors and effector molecules, which mediate detection and clearance of microbes such as bacteria, fungi, and parasites. VertebrateDrosophila as a genetically tractable organism with a This thesis concerns the peptidoglycan recognition protein (PGRP) gene family in the fruit fly. LÄS MER

  3. 3. Peptidoglycan regulation of Drosophila immunity

    Författare :Jenny Karlsson; Håkan Steiner; Kenneth Söderhäll; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Molekylärbiologi; molekylärgenetik; Molecular Genetics;

    Sammanfattning : Innate immunity is an ancient defense system that distinguishes between self and non self and is present in both vertebrates and invertebrates. Peptidoglycan (PGN), a cell wall component shared by both gram-negative and gram-positive bacteria, is the major recognition molecule for the detection of bacteria in Drosophila. LÄS MER

  4. 4. Communicate or die : signalling in Drosophila immunity

    Författare :Karin Borge-Renberg; Dan Hultmark; Michéle Crozatier; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Drosophila; innate immunity; PGRP-LC; pattern recognition; JNK; antimicrobial peptides; Molecular biology; Molekylärbiologi;

    Sammanfattning : In general the work behind this thesis has revolved around the interesting pattern recognition gene family PGRPs (peptidoglycan recognition proteins). In particular the transmembrane PGRP-LC and to investigate its multifaceted role in the immune response of the fruit fly. LÄS MER

  5. 5. The calcitonin gene family of peptides : receptor expression and effects on bone cells

    Författare :Susanne Granholm; Ulf Lerner; Pernilla Lundberg; Göran Andersson; Umeå universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; CT family of peptides; osteoclast differentiation; bone resorption; CTR; CRLR; RAMPs; Cell biology; Cellbiologi;

    Sammanfattning : The calcitonin gene family of peptides consists of calcitonin (CT), two calcitonin gene related peptides (α-CGRP, β-CGRP), adrenomedullin (ADM), amylin (AMY), three calcitonin receptor activating peptides (CRSP1-3) and intermedin/adrenomedullin2 (IMD). These peptides bind to one of two G protein -coupled receptors, the calcitonin receptor (CTR) or the calcitonin receptor-like receptor (CRLR). LÄS MER