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Visar resultat 1 - 5 av 42 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Functional characterization of the liopsarcoma-associated fusion oncigene FUS-DDIT3

    Författare :Melker Göransson; Göteborgs universitet; []
    Nyckelord :Myxoid round cell liposarcoma; fusion oncogenes; FUS; DDIT3; tumor development; cell cycle regulators; IL6; IL8; NFkappaB.;

    Sammanfattning : Fusion genes represent a growing class of translocation-derived potent oncogenes that frequently show tumor type-specific expression. We have studied the myxoid/round cell liposarcoma (MLS/RCLS)-specific FUS-DDIT3 fusion, with the aim of functionally characterizing this fusion oncogene in sarcoma development. LÄS MER

  3. 2. Inflammation and prostate carcinogenesis : influence of immune characteristics and early-adulthood exposure to inflammatory conditions on prostate cancer risk

    Författare :Henrik Ugge; Katja Fall; Sabina Davidsson; Jessica Carlsson; Ove Andrén; Lars Henningsohn; Örebro universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; inflammation; Cutibacterium acnes; acne; appendicitis; cytokines; circulating; inflammation marker; IL6; CXCL8;

    Sammanfattning : Chronic inflammation has been implicated in the development of several types of cancer, and evidence from observational and animal studies suggests that it may play a role also in prostate carcinogenesis. Recent observations have brought Cutibacterium acnes (C. acnes) forward as a possible causative agent in pro-oncogenic prostatic inflammation. LÄS MER

  4. 3. Interleukin 6 trans-signalling : cardiovascular risk marker or therapeutical target?

    Författare :Louise Ziegler; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: Interleukin (IL) 6 signals in two pathways. In classical signalling, essential in antimicrobial defence and tissue regeneration, IL6 binds the membrane- bound IL6 receptor (IL6R) which associates with the signal transducing receptor gp130. LÄS MER

  5. 4. Cardiovascular effects of short-term exposure to air pollution : exploring potential pathways and susceptible subgroups

    Författare :Petter Ljungman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cardiovascular disease is the most common cause of mortality globally, with a number of contributing risk factors. Ambient air pollution represents a universally present risk factor with a substantial preventive potential. LÄS MER

  7. 5. Anastomotic leakage in colorectal surgery : early diagnosis and treatment with stent

    Författare :Ioannis Oikonomakis; Kjell Jansson; Tal M. Hörer; Pär Myrelid; Örebro universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; anastomotic leakage; colorectal cancer; intraperitoneal microdialysis; cytokines; mRNA analysis; stent;

    Sammanfattning : Every year inn Sweden more than 6000 individuals are diagnosed with colorectal cancer and more than 5000 operations are performed. Anastomotic leakage (AL) is the most dreaded complication in colorectal surgery and has a great impact on postoperative morbidity and mortality. LÄS MER