Sökning: "IL2"

Visar resultat 6 - 10 av 11 avhandlingar innehållade ordet IL2.

  1. 6. Inheritance of autoimmune neuroinflammation

    Författare :Pernilla Stridh; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Multiple sclerosis (MS) is a chronic neuro-inflammatory disease with anticipated complex etiology. Susceptibility to MS is conferred by numerous genes, with very low odds ratios that explain minute fractions of disease. This indicates that unknown factors are responsible for the remaining genetic contribution, termed the missing heritability. LÄS MER

  3. 7. Novel immunotherapies for metastatic melanoma - from mouse models towards clinical trials

    Författare :Elin Forsberg; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Metastatic melanoma; uveal melanoma; patient-derived xenograft; immune-humanized mouse model; immunotherapy; adoptive T cell therapy; tumor-infiltrating lymphocytes; chimeric antigen receptor T CAR-T cells;

    Sammanfattning : Immunotherapies including checkpoint blockade and adoptive T cell transfer (ACT) show great promise for the treatment of melanoma, with long-term effects in some patients. However, around half of the patients with metastatic malignant melanoma will not be cured with available therapies today, and these patients require other treatment strategies. LÄS MER

  4. 8. Novel immunotherapies for metastatic uveal melanoma - From bench to clinical biomarkers

    Författare :Vasu R. Sah; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Immunotherapy has revolutionized cancer treatment, with durable long-term effects in a proportion of patients. However, in around half of these patients, there are little to no effects. Patients with metastatic uveal melanoma (mUM), a rare form of melanoma originating from the eye has lack of effective treatments. LÄS MER

  5. 9. Chronic leukemic B-cell disorders and trisomy 12 : a study of surface markers, protein expression and clinical course

    Författare :Viktoria Hjalmar; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Chronic lymphocytic leukemia of B-cell type (CLL) is the most common disease entity of chronic leukemic B-cell disorders (CLBD). CLL is the most frequent leukemia in the Western world and the incidence is increasing. The clinical course is very variable and specific therapy is not always needed. LÄS MER

  7. 10. Modulation of mononuclear phagocyte function in the dissemination of Toxoplasma gondii

    Författare :Arne L. ten Hoeve; Antonio Barragan; Nicolas Blanchard; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Apicomplexa; dendritic cell; macrophage; intracellular signaling; parasite-derived effector protein; chemotaxis; leukocyte migration; transcription factor; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : Toxoplasma gondii is an obligate intracellular Apicomplexan parasite that could possibly infect all warm-blooded animals. Acute infections with T. LÄS MER