Sökning: "IL-22."

Visar resultat 6 - 10 av 17 avhandlingar innehållade ordet IL-22..

  1. 6. Resident T cells in human skin : functional heterogeneity and clinical implications

    Författare :Stanley Sing Hoi Cheuk; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The skin forms a critical barrier against the external environment and is therefore frequently challenged by infections and subjected to immune-mediated diseases as well as malignancies. The Tissue-Resident Memory T (TRM) cell is a subset of T cells that resides at sites of previous infection in the skin and other epithelial tissues. LÄS MER

  3. 7. Immunological Studies using Human and Canine Model Disorders

    Författare :Kerstin M. Ahlgren; Anna Lobell; Olle Kämpe; Kerstin Lindblad-Toh; Roland Jonsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Autoimmunity; T cell; T helper cell; B cell; Autoantibodies; Interferon; Interleukin; Dogs; APS-1; Candida albicans; fungus; Immunologi; Immunology; Medicin; Medicine;

    Sammanfattning : The studies presented in this thesis focus on human and canine models for autoimmune disease, with the main aim to gain new knowledge about disease mechanisms and to further evaluate the dog as a model for autoimmune disease. Autoimmune Polyendocrine Syndrome type 1 (APS-1) is a hereditary human multiorgan disease caused by mutations in the autoimmune regulator (AIRE) gene. LÄS MER

  4. 8. The functional role of the MUC17-based glycocalyx

    Författare :Sofia Jäverfelt; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Intestine; Glycocalyx; Membrane mucin; Host defenses;

    Sammanfattning : Our gastrointestinal tract harbors trillions of bacteria that are chemically and spatially separated from the intestinal epithelium. Maintaining an intact mucosal barrier is essential as increased bacterial contact is associated with inflammatory bowel diseases such as Crohn´s disease. LÄS MER

  5. 9. Tuberculosis - Clinical Value of Initial Host Molecular Signalling and Molecular Fingerprinting

    Författare :Nader Alaridah; Malmö Medicinsk mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Mycobacterium tuberculosis (Mtb) is principally a pulmonary pathogen infecting one-third of the world's population and causing two million deaths annually. The only approved tuberculosis vaccine today is the Mycobacterium bovis bacilli Calmette-Guérin (BCG). LÄS MER

  7. 10. Gene regulation in psoriatic keratinocytes : microRNAs and cytokine responses

    Författare :Ankit Srivastava; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Psoriasis is the most common chronic skin inflammation in adults which affects 2-4% of the world population. Keratinocytes are the key structural cells in epidermis which hyper-proliferate and undergo aberrant differentiation in psoriasis. LÄS MER