Sökning: "IL-22."

Visar resultat 11 - 15 av 17 avhandlingar innehållade ordet IL-22..

  1. 11. In situ characterization of immune cells mediating potential control of HIV infection in the female genital mucosa

    Författare :Anna Gibbs; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Heterosexual HIV transmission is the most common viral transmission route, worldwide, where young women are more susceptible to HIV infection than men. To establish a persistent infection the virus needs to cross the mucosal surface of the female genital tract (FGT). LÄS MER

  3. 12. Innate lymphoid cells and cholesterol metabolism in intestinal barrier function

    Författare :Sara Martina Parigi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The intestinal mucosa represents one of the largest barrier sites of our body, having to withstand a constant exposure to a plethora of environmental insults (including dietary compounds, xenobiotics, metabolites and microorganisms). While our body has evolved tolerance/ignorance towards some of these factors deemed beneficial for the host, it requires constant maintenance of epithelial barrier integrity and ability to mount pro-inflammatory responses to protect against potentially harmful environmental insults. LÄS MER

  4. 13. Resident T cells steer tissue responses in human skin

    Författare :Borislav Ignatov; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The human skin constitutes a biological barrier against threats to the body from the surrounding environment. Tissue-resident memory cells (TRM) reside in the skin and provide local memory of previous encounters with microbes and pathogens, are poised to promptly eliminating infected cells and elicit tissue-wide defense state. LÄS MER

  5. 14. Clinical and genetic stratification of childhood psoriasis

    Författare :Josefin Lysell; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Psoriasis is a clinically heterogeneous and common disease affecting about 2-3% of the population in Sweden. Twin and family studies have shown a strong and complex genetic background in psoriasis. The strongest known linkage association is for HLA-C*06 on chromosome 6p21.3. LÄS MER

  7. 15. Mechanisms of resident T cell-driven tissue responses during the onset and recurrence of human skin inflammation

    Författare :Irène Gallais Sérézal; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Long-lived tissue-resident memory T cells (TRM) reside in nonlymphoid organs and can drive direct cytotoxicity, focal cytokine release and potent tissue-wide anti-infectious responses upon antigenic challenge. TRM cells poised to pathogenic responses have been identified in active and resolved psoriasis and mice models of allergic contact dermatitis (ACD). LÄS MER