Sökning: "IL-18"

Visar resultat 6 - 10 av 63 avhandlingar innehållade ordet IL-18.

  1. 6. Innate immunity of human intestinal epithelium in childhood celiac disease : influences from celiac disease associated bacteria and dietary oats

    Författare :Grzegorz Pietz; Marie-Louise Hammarström; Thomas T MacDonald; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Celiac disease; dietary oats; gut microbiota; intestinal epithelium; IEL; IFN-γ; IRF1; IL-18; CXC3L1; inflammasome; permeability; Prevotella jejuni; Lachnoanaerobaculum umeaense; immunologi; Immunology;

    Sammanfattning : Background & Aims: Celiac disease (CD) is a chronic inflammatory small-bowel enteropathy caused by permanent intolerance to gliadin in wheat gluten, and related proteins in ray and barley. It is disputed whether CD patients tolerate oats. The only treatment of CD is lifelong gluten-free diet (GFD). LÄS MER

  3. 7. Vibrio cholerae modulates the immune defense of human gut mucosa

    Författare :Aziz Bitar; Marie-Louise Hammarström; Sun Nynt Wai; Mikael Rehn; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Vibrio cholerae; intestinal epithelial cell; duodenum biopsy; acute cholera; immunomodulation; microRNA; OMV; cytokine; T84 monolayer; miR-146; miR-155; VCC; PrtV; hemolysis; IL-8; TNF-a; IL-1b; IL-18; CCL20; IRAK2; inflammation; mikrobiologi; Microbiology; immunologi; Immunology;

    Sammanfattning : The key function of innate immunity is to sense danger signals and initiate effective responses as a defense mechanism against pathogens. Simultaneously, effector responses must be regulated to avoid excessive inflammation with resulting tissue damage. LÄS MER

  4. 8. Role of cytokines in experimental neurodegenerative and neuroinflammatory disorders

    Författare :Xing-Mei Zhang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Altered expression of cytokines in response to body injury has diverse actions that can exacerbate, mediate, reduce or inhibit neuronal and myelin damage as well as influence the disease development in a variety of nervous system disorders, such as Alzheimer s disease (AD), multiple sclerosis and Guillain-Barré Syndrome (GBS). In these studies, we attempted to explore the possible roles of tumor necrosis factor (TNF)-α and interleukin (IL)-18 in experimental neurodegenerative and neuroinflammatory disorders. LÄS MER

  5. 9. Innate mechanisms regulating B cell activation in inflammatory diseases

    Författare :Sara Lind; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Generation of powerful and highly specific immune responses against invading pathogens is essential to our survival. However, the immune system can cause disease if activated in an inappropriate manner. LÄS MER

  7. 10. Antimicrobial and xenobiotic defence in the mammalian testis

    Författare :Mona-Lisa Strand; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Different mechanisms exist in the mammalian testis to protect the germ cells from autoimmune attack, invading microbes, and xenobiotic induced toxicity, which would otherwise be deleterious to the preservation of fertility. The general aim of this thesis was to study these testicular defence mechanisms, including the structural building blocks of the blood– testis barrier (BTB), antimicrobial peptides, proinflammatory cytokines and ATP-binding cassette (ABC) transporter proteins. LÄS MER