Sökning: "IL-15"

Visar resultat 21 - 25 av 37 avhandlingar innehållade ordet IL-15.

  1. 21. Antibody-based Cancer Immunotherapy : Personalization, response prediction and safety considerations

    Författare :Mohamed Eltahir; Sara Mangsbo; Patrick Micke; Gustav Ullenhag; Marit Inderberg; Uppsala universitet; []
    Nyckelord :;

    Sammanfattning : Antibody-based therapeutics have remarkably improved the field of immuno-oncology. Multiple monoclonal antibodies (mAbs) are approved for clinical use, and numerous antibodies are under clinical development. The scope of this thesis is to study the personalization of antibody-based immunotherapeutics and tools to predict their efficacy and safety. LÄS MER

  3. 22. Regulation of the pro-apoptotic protein Bim by T cell receptor triggering in human T cells

    Författare :Elena Sandalova; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Bim; Apoptosis; Mitochondria; CTLs; AICD; TCR activation;

    Sammanfattning : Bim is a significant pro-apoptotic member of Bcl-2 family of proteins; it is proved to be an important regulator of apoptosis: over the years it has been shown to play a pivotal role for the development and maintenance of homeostasis in many cellular systems and tissues. The Bcl-2 family of proteins is a group of key regulators of the mitochondrial, or intrinsic, pathway of apoptosis. LÄS MER

  4. 23. Human natural killer cell activation and differentiation in health and viral infection

    Författare :Niklas Björkström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Natural killer (NK) cells are lymphocytes that belong to the innate immune system. They are important for the early defense against viral infections and provide tumor Immune surveillance against both solid tumors and leukemias as well as in settings of hematopoietic stem cell transplantation. LÄS MER

  5. 24. Resident T cells in human skin : functional heterogeneity and clinical implications

    Författare :Stanley Sing Hoi Cheuk; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The skin forms a critical barrier against the external environment and is therefore frequently challenged by infections and subjected to immune-mediated diseases as well as malignancies. The Tissue-Resident Memory T (TRM) cell is a subset of T cells that resides at sites of previous infection in the skin and other epithelial tissues. LÄS MER

  7. 25. Compartmentalisation of the immune response in human skin : cross-talk between dendritic cells and T cells in healthy conditions and in psoriasis

    Författare :Elisa Martini; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Human skin is highly compartmentalised and distinct subsets of dendritic cells (DCs) and T cells reside in epidermis and dermis. Alterations in the composition of DCs and T cells have been observed in psoriasis, a common cytokine-driven focal inflammatory skin disease. LÄS MER