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Visar resultat 1 - 5 av 37 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Regulation of growth, differentiation and survival of B-chronic lymphocytic leukemia cells

    Författare :Ola Söderberg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pathology; B-CLL; B cells; IL-2; IL-4; IL-10; IL-15; CD40-stimulation; SAC; Thioredoxin; proliferation; differentiation; survival; in vitro; EBV; Patologi; Pathology; Patologi; Pathology; patologi;

    Sammanfattning : Chronic lymphocytic leukemia of B cell type (B-CLL) is the most commonform of leukemia in the Western countries. The signals regulating theexpansion of the B-CLL clone in vivo is yet far from being fully understood. LÄS MER

  3. 2. Interleukin 15 and 17 in Staphylococcus aureus arthritis

    Författare :Louise Henningsson; Göteborgs universitet; []
    Nyckelord :Staphylococcus aureus; Interleukin-17A; Interleukin-15; arthritis; osteoclasts; IL-23;

    Sammanfattning : Staphylococcus aureus–induced arthritis leads to severe joint destruction and high mortality despite antibiotic treatment. Thus, there is a need to identify new treatment targets in addition to antibiotic therapy. Interleukin (IL)-15 has been implicated both in osteoclastogenesis and in bacterial clearance – two important issues in S. LÄS MER

  4. 3. Interleukin 15 throughout murine natural killer cell biology

    Författare :Thuy Thanh Luu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Natural killer (NK) cells are innate immune cells that mount responses against virally infected, transformed and allogeneic transplanted cells. Equipped with cytolytic molecules and death receptors, NK cells mediate cytotoxicity against cells expressing low levels of MHC class I (MHC-I) or high levels of stress-induced molecules. LÄS MER

  5. 4. From natural to eximious : harnessing the power of natural killer cells against solid tumors

    Författare :Ziqing Chen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cancer heterogeneity, which enables clonal survival and treatment resistance, is shaped by active immune responses. Unchallenged results from clinical trials show the power of stimulating our immune system to attack tumor cells. Engineered T cells and checkpoint blockade are at the forefront of current immunotherapy strategies. LÄS MER

  7. 5. Polymyositis and dermatomyositis : inflammation, muscle structure and immunosuppressive treatment

    Författare :Ingela Loell; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Polymyositis and dermatomyositis are chronic, inflammatory disorders characterized by muscle weakness, low muscle endurance and by inflammation in skeletal muscle tissues. The pathogenesis is not completely understood and several mechanisms are believed to be involved. LÄS MER