Sökning: "IL-10"

Visar resultat 11 - 15 av 300 avhandlingar innehållade ordet IL-10.

  1. 11. Immunity and immunosuppression in the tumor-host interaction

    Författare :Max Petersson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Tumors; MHC class 1; natural processed peptides; T cells; NK cells; IFN-[gamma]; IL-10; TAP;

    Sammanfattning : With the advent of new methods in molecular biology and in peptide isolation, a number of tumor-associated antigens and their epitopes have been identified and characterized. However, tumors often grow progressively evolving different mechanisms of immune escape, resulting in resistance to MHC class I-restricted tumor-specific T cells. LÄS MER

  3. 12. T lymphocytes in Wegener’s granulomatosis

    Författare :Ricardo Antonio Giscombe Stephen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Wegener s granulomatosis; T lymphocytes; TCR; T cell expansions; HLA-DRB1*0401; CTLA-4; IL-10;

    Sammanfattning : Wegener's granulomatosis (WG) is a systemic necrotizing vasculitis that affects small and medium size blood vessels. The respiratory tract and lungs are usually compromised with necrotizing granulomatous formations. The aetiology is unknown and untreated the prognosis of generalised WG is very poor. LÄS MER

  4. 13. SLE : pathogenetic mechanisms in nephritis and sulphasalazine-induced lupus reactions

    Författare :Iva Gunnarsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :systemic lupus erythematosus; IgA nephropathy; rheumatoid arthritis; anti-C1q antibodies; nephritis; C1q; IL-10; drug-induced; sulphasalazine;

    Sammanfattning : Systemic lupus erythematosus (SLE) is an autoimmune disease with a multifactorial and largely unknown etiology, in which genetic and environmental factors are known to influence disease susceptibility and expression. Nephritis is a common and severe disease manifestation in which immune complexes and complement deposits in the renal tissue are invariably seen. LÄS MER

  5. 14. Cytokine-modulated dendritic cell immunotherapy in autoimmune diseases

    Författare :Sanjaya Bandara Adikari; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Autoimmunity is the result of failure of self-tolerance processes. When the immune system fails to differentiate self from foreign, the effector mechanisms are directed towards the individual s own tissues, and pathological autoimmune disease results. LÄS MER

  7. 15. Tumor recognition by cytotoxic T cells : definition of new tumor antigens and the effect of interleukin-10 on antigen presentation

    Författare :Flavio Salazar-Onfray; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The tumor antigens against which T cell responses have been demonstrated most frequently are not tumor specific but are also expressed on normal tissues. This observation has been interpreted as evidence for breaking of immunological tolerance to normal cellular proteins. LÄS MER