Sökning: "IL-1"
Visar resultat 16 - 20 av 139 avhandlingar innehållade ordet IL-1.
16. Molecular and functional studies of interleukin-1a in the rat testis
Sammanfattning : The aim of the present study was to gain a better insight into the role of interleukin-1 alpha (IL-1 alpha) in testicular physiology. In testis, IL-1alpha acts as a paracrine mediator involved in the regulation of testicular functions. LÄS MER
17. The Interleukin-1 family of proteins in the brain and adrenal gland : regulation in response to bacterial LPS
Sammanfattning : Interleukin-1 (IL-1) is mediating diverse physiological conditions as inflammatory response, fever and sickness behaviour but also, via activation of the hypothalamus-pituitary-adrenal (HPA)-axis, the release of the anti-inflammatory adrenocorticoids. The neuroendocrine system as well as the central nervous system (CNS) is involved in the regulation of these conditions in the body. LÄS MER
18. Studies of cytokine mediated regulation of central nervous functions : role of prostaglandins
Sammanfattning : The communication between the immune system and the central nervous system (CNS) results in an array of centrally regulated illness responses, including fever and increased hypothalamus-pituitary-adrenal (HPA) axis activity. The mechanisms by which the immune system signals the brain across the blood-brain barrier have not been completely elucidated, but proinflammatory cytokines, like interleukin-1 (IL-1), are believed to act as important mediators. LÄS MER
19. Interleukin-1 Receptors and their Ligands
Sammanfattning : Interleukin-1 (IL-1) is an endogenous mediator of the inflammatory response. IL-1 executes its actions by binding and subsequent activation of the IL-1 receptor (IL-1R) proteins. Among the many systemic effects of IL-1, the fever response was the first to be investigated. LÄS MER
20. Blocking interleukin-1 signalling in the brain-structural and functional outcomes
Sammanfattning : The aims of this thesis were to evaluate the consequences of blocking interleukin (IL)-1 signalling in the brain. The studies used a transgenic mouse model with brain-directed overexpression of the human soluble isoform of IL-1 receptor antagonist with the GFAP promoter (Tg hsIL-1ra). LÄS MER