Sökning: "IGFBP-I"
Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet IGFBP-I.
1. Genetic and non-genetic influences on some metabolic cardiovascular risk factors : quantitative genetic analyses
Sammanfattning : Structural-equation modeling analyses were applied to data from 302 Swedish twin pairs in order to assess the relative importance of genetic and nongenetic influences on several metabolic cardiovascular risk factors. These middle-aged and elderly twins include monozygotic and dizygotic twins reared apart and together, who came from a population-based national twin register. LÄS MER
2. Osteoporosis, balance and nutrition in elderly women in primary care
Sammanfattning : Objective: Some people get skeletal fractures as a result of a trauma which wouldn’t cause a fracture in a healthy individual. These fractures are sometimes referred to as “fragility fractures”. Common sites for fragility fractures are the spine, hip, upper arm, shoulder, distal forearm and pelvis. LÄS MER
3. Nutritional status before and during pregnancy in relation to the maternal insulin-like growth factor-system and health related variables in the offspring
Sammanfattning : Adequate fetal growth is of importance for health in adulthood. Maternal nutritional status has been suggested to be one major factor influencing fetal development. LÄS MER
4. Insulin and IGF-I in type 1 diabetes
Sammanfattning : Patients with type I diabetes have alterations in the GH/IGF system with reduced levels of circulating IGF-I, as well as other disturbances in the components of the IGF system.Alterations of both local and circulating IGF-I and its binding proteins (IGFBPs) have been associated with metabolic and vascular manifestations of diabetes and also with atherosclerosis. LÄS MER
5. Regulation of insulin-like growth factor binding protein-1 (IGFBP-1) and implications in catabolic conditions
Sammanfattning : This thesis has studied the regulation of IGFBP-1 (insulin-like growth factor binding protein 1), which is one factor regulating the bioavailability of IGF-I with special interest how IGFBP-1 is regulated in vitro and in humans, especially in diabetes and catabolic conditions. The IGFBP-1 cDNA was cloned and used for studies in human hepatoma cells, HepG2, which showed that both insulin and IGF-I could decrease IGFBP-1 in the cell conditioned medium. LÄS MER