Sökning: "IGFBP-1"

Visar resultat 21 - 25 av 43 avhandlingar innehållade ordet IGFBP-1.

  1. 21. The GH/IGF-1 system during surgery and catabolism : focus on metabolism and heart function

    Författare :Mats Wallin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : GH plays a role in both anabolism and catabolism. The anabolic properties of GH are mediated by circulating (endocrine) and locally secreted (paracrine) IGF-1. It is thus the IGF-1 response after increased GH secretion that determines whether metabolism will be anabolic or catabolic. LÄS MER

  3. 22. Heart failure : role of metabolic biomarkers, ejection fraction, and sex

    Författare :Ulrika Ljung Faxén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: Heart failure (HF) is common and associated with impaired quality of life (QoL) and poor prognosis. There is a ternary classification of HF based on ejection fraction (EF): HF with preserved(HFpEF), mid-range EF(HFmrEF), and reduced EF(HFrEF). LÄS MER

  4. 23. Receptor-operated signaling pathways in normal and diabetic pancreatic islet cell function

    Författare :Fan Zhang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Loss of glucose-dependent insulin release is an early pathogenetic event in human type 2 diabetes. Impaired glucose-mediated insulin secretion from pancreatic islet β-cells leads to insulin deficiency and thus hyperglycemia. LÄS MER

  5. 24. Genetic and epigenetic studies of diabetes and diabetic nephropathy with focus on the IGF-IGFBP axis

    Författare :Tianwei Gu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Diabetes and diabetic nephropathy (DN) are complex diseases reflecting a complex interplay between genetic and non-genetic factors. The insulin-like growth factor (IGF) - IGF binding protein (IGFBP) axis plays an important role in the development of diabetes and DN. LÄS MER

  7. 25. Genetic design for facilitated production of human peptide hormones inEscherichia coli

    Författare :Per Jonasson; KTH; []
    Nyckelord :;

    Sammanfattning : Genetic strategies have become important in the design ofefficient processes for production of recombinant proteins.When constructing a production scheme, inherent properties,purity and quality requirements, as well as the final use ofthe protein, have to be considered. LÄS MER