Sökning: "IGFBP-1. IGFBP-3"
Visar resultat 1 - 5 av 10 avhandlingar innehållade orden IGFBP-1. IGFBP-3.
1. Regulation of insulin-like growth factor binding protein-1 (IGFBP-1) and implications in catabolic conditions
Sammanfattning : This thesis has studied the regulation of IGFBP-1 (insulin-like growth factor binding protein 1), which is one factor regulating the bioavailability of IGF-I with special interest how IGFBP-1 is regulated in vitro and in humans, especially in diabetes and catabolic conditions. The IGFBP-1 cDNA was cloned and used for studies in human hepatoma cells, HepG2, which showed that both insulin and IGF-I could decrease IGFBP-1 in the cell conditioned medium. LÄS MER
2. Novel insulin-like growth factor-binding protein proteases : detection and characterization
Sammanfattning : Members of the insulin-like growth factor (IGF) system are known to have an impact on cell differentiation, proliferation and survival, and to be important regulators for nutrient metabolism. The IGF-binding proteins (IGFBP-1 to -6) control the availability of IGFs (IGF-I and IGF-II) to their receptors. LÄS MER
3. Diabetes and puberty : studies on hormonal factors of importance to the blood glucose control
Sammanfattning : It is well known that, in children with type 1 diabetes, metabolic control often deteriorates during puberty. Better understanding of the mechanisms that cause deterioration of blood glucose control can lead to improved therapeutic approaches. LÄS MER
4. The IGF-IGFBP system in aerobic exercise : with focus on skeletal muscle
Sammanfattning : Activity induced skeletal muscle adaptation has been suggested to be mediated largely by intrinsic factors, such as insulin-like growth factor (IGF)-I. IGF-I stimulates muscle glucose and amino acid uptake and promotes anabolism. LÄS MER
5. The insulin-like growth factor system : effects of circulating proteases
Sammanfattning : The insulin-like growth factor-I and -II (IGF-I/-II) are peptide hormones important for growth and metabolism. They stimulate cell proliferation and differentiation and inhibit apoptosis. In addition, they have insulin-like effects on glucose and amino acid metabolism. LÄS MER