Sökning: "IGFBP protease"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden IGFBP protease.

  1. 1. The IGF-IGFBP system in aerobic exercise : with focus on skeletal muscle

    Författare :Ulrika Berg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; IGF-I; IGFBP-1; microdialysis; exercise; IL-6; calpain;

    Sammanfattning : Activity induced skeletal muscle adaptation has been suggested to be mediated largely by intrinsic factors, such as insulin-like growth factor (IGF)-I. IGF-I stimulates muscle glucose and amino acid uptake and promotes anabolism. LÄS MER

  2. 2. Novel insulin-like growth factor-binding protein proteases : detection and characterization

    Författare :Jing Wang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; IGFs; IGFBP-1. IGFBP-3; azurocidin HBP CAP37; IGFBP protease; gender;

    Sammanfattning : Members of the insulin-like growth factor (IGF) system are known to have an impact on cell differentiation, proliferation and survival, and to be important regulators for nutrient metabolism. The IGF-binding proteins (IGFBP-1 to -6) control the availability of IGFs (IGF-I and IGF-II) to their receptors. LÄS MER

  3. 3. Diabetes and puberty : studies on hormonal factors of importance to the blood glucose control

    Författare :Ingmar Zachrisson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Type 1 diabetes; Puberty; Adolescence; Metabolic Control; IGF-I; IGFBP-1; IGFBP-3; Proteases; Leptin;

    Sammanfattning : It is well known that, in children with type 1 diabetes, metabolic control often deteriorates during puberty. Better understanding of the mechanisms that cause deterioration of blood glucose control can lead to improved therapeutic approaches. LÄS MER

  4. 4. Proteolysis of insulin-like growth factor-binding protein-1, -2 and -4 : function of fragments

    Författare :Katrin Brandt; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Insulin-like growth factor;

    Sammanfattning : The insulin-like growth factors (IGF-I and IGF-II) stimulate cell growth, survival and differentiation, and have insulin-like activity. A family of six IGF-binding proteins (IGFBP-1 through -6) bind to IGFs with high affinity and modulate their activity in the circulation and locally at cell-surface receptors. LÄS MER

  5. 5. The insulin-like growth factor system : Effects of circulating proteases

    Författare :Sara Gustafsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Sammanfattning : The insulin-like growth factor-I and -II (IGF-I/-II) are peptide hormones important for growth and metabolism. They stimulate cell proliferation and differentiation and inhibit apoptosis. In addition, they have insulin-like effects on glucose and amino acid metabolism. LÄS MER