Sökning: "IGF1"

Visar resultat 11 - 15 av 19 avhandlingar innehållade ordet IGF1.

1. 11. Studies on Tissue Factor with Focus on Cell Signaling and Cancer

   Författare :Oskar Eriksson; Agneta Siegbahn; Lina Badimon; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tissue Factor; blood coagulation; cell signaling; protease; mass spectrometry; immunohistochemistry; colorectal cancer; apoptosis; Eph receptor; Klinisk kemi; Clinical Chemistry; Molekylär cellbiologi; Molecular Cellbiology;

   Sammanfattning : This thesis have explored the functions of the protein Tissue Factor (TF), which together with its ligand coagulation factor VII/VIIa (FVII/FVIIa) forms a proteolytic complex that functions in initiation of blood coagulation and activation of cell signaling.In paper I, the mechanisms behind the observation that TF/FVIIa signaling protects cells from apoptosis were further investigated. LÄS MER

3. 12. Stem cell signatures in glioma

   Författare :Xiaobing He; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Gliomas are the most common tumors of the central nervous system in adults. Glioblastoma, the most aggressive form, has a median survival of 15 months regardless of the standard treatment with surgery and temozolomide-based radiochemotherapy. Therefore, it is imperative to improve treatment options for patients with glioblastoma. LÄS MER

4. 13. Building muscle : a translation of training adaptation

   Författare :Niklas Boman; Michael Svensson; Jonas Burén; Henrik Antti; Eva Jansson; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Training; adaptation; muscle; human; hypertrophy; testosterone; fysiologi; Physiology;

   Sammanfattning : Training is preparation for what is expected to come through utilization of the plastic and resistive features of nature, known as adaptation. As such, training in humans may have a number of desired goals. These are typically related to sports performance or education. Whatever the goal, a plan needs to be made for reaching it. LÄS MER

5. 14. Signaling to the immature brain - Choroid plexus, insulin-like growth factor 1 and extracellular vesicles

   Författare :Niklas Ortenlöf; Lund Pediatrik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IGF-1; Choroid plexus; Immature brain; Extracellular vesicle; CSF; Preterm infants;

   Sammanfattning : Extremely preterm infants (i.e., born below 28 gestational weeks), are at high risk of developing brain morbidities including intraventricular hemorrhage (IVH) and neurodevelopmental impairment. Despite over 50 years of research, there is currently no effective therapy available for preventing IVH. LÄS MER

7. 15. Tailoring Radionuclide Therapy of Neuroendocrine Tumors - Bridging the Gaps

   Författare :Anna Sundlöv; Tumörmikromiljö; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; 177Lu-DOTATATE; PRRT; somatostatin analogs; pituitary function; renal function; dosimetry; 68Ga-DOTATATE; individualized treatment; neuroendocrine tumors;

   Sammanfattning : Background and Aims: Radionuclide therapy is systemic, targeted radiotherapy. As such, we can apply the basic principles of radiobiology used in everyday practice in radiation oncology, as a means of tailoring the treatment to each patient and optimizing the balance between efficacy and toxicity. LÄS MER