Sökning: "IGF-1R cyclin D1"

Hittade 5 avhandlingar innehållade orden IGF-1R cyclin D1.

  1. 1. The secret life of nuclear IGF-1R : functions beyond traditional signaling pathways

    Författare :Dudi Warsito; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The implications of IGF-1R in normal development and disease are well established. IGF-1R plays pivotal roles in cell proliferation and cell survival and aberrant activation result in tumorigenesis and cancer progression. LÄS MER

  3. 2. The many faces of IGF-1R from cell surface to the nucleus

    Författare :Sandra Andersson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The IGF-1R is due to its implication in cancer an intensively studied subject of research. It is well known today that intracellular signals mediated by the IGF-1R play pivotal roles in tumorigenesis and cancer progression. LÄS MER

  4. 3. The biological role and clinical impact of SYT-SSX fusion gene and IGF-1R in synovial sarcoma

    Författare :Yuntao Xie; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Synovial sarcoma; translocation; SYT-SSX; IGF-1R cyclin D1; cell cycle; proliferation; apoptosis.;

    Sammanfattning : Synovial sarcoma, which is a highly malignant soft tissue tumour occurring mainly in young and middle-aged adults, is characterized by the translocation t(X; 18)(p 11.2; q 11.2). LÄS MER

  5. 4. From membrane to nucleus : new roles and functions of SUMOylated IGF-1R and EGFR

    Författare :Sylvia Packham; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cell surface receptor tyrosine kinases (RTKs) role in cell signaling have been studied for decades and their role in cancer progression are undisputable. The insulin-like growth factor 1 receptor, IGF-1R, has been demonstrated to play a critical part in tumorigenesis; downregulation of the IGF-1R in tumor xenografts results in complete tumor regression. LÄS MER

  7. 5. Synovial sarcoma : molecular, biological and clinical implications

    Författare :Maria Törnkvist; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :synovial sarcoma; translocations; fusion genes; SS18-SSX; IGF-1R; cyclin D1; antisense oligodeoxynucleotides.;

    Sammanfattning : Synovial sarcoma is a rare but mostly aggressive soft tissue tumor that mainly affects children and young adults. The tumor usually occurs in the vicinity of large joints, and may be subdivided into a classical biphasic type, a monophasic type or a poorly differentiated type, depending on histomorphological appearance. LÄS MER