Sökning: "IGF-1"

Visar resultat 6 - 10 av 102 avhandlingar innehållade ordet IGF-1.

  1. 6. Gene therapy in a new model of delayed wound healing

    Författare :Patrik Velander; Kirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IGF-1; Gene therapy; Diabetes; Animal model; EGF;

    Sammanfattning : Diabetes wounds result in significant morbidity, prolonged hospitalization and huge health care expenses. As of yet, no optimal animal models of diabetic wound healing exist to study potential beneficial therapies. Porcine wound healing is very similar to human wound healing. LÄS MER

  3. 7. Molecular Mechanisms of Graves' Ophthalmopathy. A focus on smoking and radioiodine

    Författare :Bushra Shahida; diabetes och endokrinologi Genomik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Graves’ disease. Graves’ ophthalmopathy; radioiodine; inflammation; adipogenesis; IL-1ß; IL-6; PTGS2 COX2; PGE2; CTLA-4; B lymphocytes; T lymphocytes; Simvastatin; Diclofenac; SNP; gene expression; IGF-1;

    Sammanfattning : Graves’ disease (GD) is an autoimmune disease characterized by hyperthyroidism and is caused by an interplayof genetic and environmental factors. One-third of patients with GD develop Graves’ ophthalmopathy (GO). Keyprocesses in the pathogenesis of GO are inflammation and adipogenesis in orbital tissue. LÄS MER

  4. 8. Processing of the amyloid precursor protein and its paralogues amyloid precursor-like proteins 1 and 2

    Författare :Linda Adlerz; Kerstin Iverfeldt; Richard Cowburn; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; APP; APLP1; APLP2; Alzheimer s disease; Amyloid β-peptide; Processing; RA; BDNF; IGF-1; curcumin; PI3-K; MAPK; cdk5; Neurochemistry; Neurokemi; Neurochemistry and Molecular Neurobiology; neurokemi med molekylär neurobiologi;

    Sammanfattning : Alzheimer’s disease (AD) is a neurodegenerative disorder which is histopathologically characterised by amyloid plaques and neurofibrillary tangles. Amyloid plaques consist of the amyloid β-peptide (Aβ) that can form aggregates in the brain. Aβ is generated from the amyloid precursor protein (APP) through proteolytic cleavage. LÄS MER

  5. 9. Mechanisms of Sensitization to Apoptosis in Multiple Myeloma

    Författare :Anna Hammarberg; Helena Jernberg Wiklund; Kenneth Nilsson; Federico Caligaris-Cappio; Uppsala universitet; []
    Nyckelord :Pathology; multiple myeloma; apoptosis; IGF-1; mTOR; IAP; GSK3; rapamycin; PPP; dexamethasone; CT99021; Patologi;

    Sammanfattning : Multiple myeloma (MM) is a hematological tumor of plasma blast/plasma cell origin heterogeneous with respect to the morphological differentiation stage of the tumor cells, genetic alterations and course of disease. A challenge in MM research is to overcome resistance to therapy, which inevitably arises. LÄS MER

  7. 10. Targeting the GH/IGF-1 axis with novel, small molecule inhibitors

    Författare :Linda Rosengren; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The growth hormone (GH) / insulin-like growth factor (IGF) family of ligands, binding proteins and receptors play multiple roles in cell growth, metabolism and development. In addition, numerous studies have demonstrated the pathophysiological importance of the GH/IGF-1 axis. LÄS MER