Sökning: "IFN-gamma"

Visar resultat 11 - 15 av 155 avhandlingar innehållade ordet IFN-gamma.

  1. 11. Immunological responses in genital HPV infections and etiology of cervical cancer

    Författare :Lisen Arnheim; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HPV; CIN; cervical cancer; antibodies; KIRs; CXCL8; IFN-gamma; Chlamydia trachomatis;

    Sammanfattning : Cervical cancer is one of the most common forms of cancers in women. Every year approximately 450,000 women are diagnosed worldwide and 200,000 die. The sexually transmitted oncogenic human papillomavirus (HPV) types are established as the major etiological agents of cancer of the cervix. LÄS MER

  3. 12. Host control of intracellular bacterial infections

    Författare :Emma Eriksson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Listeria monocytogenes; CD44; flagellin; Chlamydia pneumoniae; TLR; NOD; IFNalpha beta; IFN-gamma;

    Sammanfattning : In this thesis various immune mechanisms regulating control of infections with the intracellular bacteria Listeria monocytogenes and Chlamydia pneumoniae have been studied. These bacteria infect macrophages in which they can successfully grow. However, macrophages are potent killers of intracellular bacteria. LÄS MER

  4. 13. Studies on uptake and effect of triclosan on production of inflammatory mediators in human gingival fibroblasts

    Författare :Manal Mustafa; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Triclosan; gingival fibroblasts; IL-beta; IFN-gamma; MHC class II; PGE2; mPGES-1;

    Sammanfattning : Triclosan (2,4,4'-trichloro-2'-hydroxy-diphenyl ether) is a lipid soluble anti-bacterial agent widely used in dentifrices, mouthrinses, soap and cosmetics. Although reports on the efficacy of triclosan on periodontal diseases are conflicting, it is documented in clinical studies that dentifrices containing triclosan reduce plaque accumulation and improve gingival health. LÄS MER

  5. 14. Studies of the recognition and activation of natural killer cells

    Författare :Clas Une; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :NK cells; activation; cytotoxicity; IFN-[gamma] IFN-[alpha] [beta]; IL-12; G-PI; MHC class I;

    Sammanfattning : Natural killer (NK) cells mediate part of the innate immune response that impedes the spread of invading microorganisms and shapes the downstream adaptive immune response. NK cells spontaneously kill tumor cells and other cells upon contact. Killing requires engagement of germline encoded receptors that mediate positive and negative signals. LÄS MER

  7. 15. Immunity and immunosuppression in the tumor-host interaction

    Författare :Max Petersson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Tumors; MHC class 1; natural processed peptides; T cells; NK cells; IFN-[gamma]; IL-10; TAP;

    Sammanfattning : With the advent of new methods in molecular biology and in peptide isolation, a number of tumor-associated antigens and their epitopes have been identified and characterized. However, tumors often grow progressively evolving different mechanisms of immune escape, resulting in resistance to MHC class I-restricted tumor-specific T cells. LÄS MER