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Visar resultat 1 - 5 av 13 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Tolerance and Immunity: Opposite Outcomes of Microbial Antigen Stimulation

    Författare :Lena Eroukhmanoff; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TLR2; Tolerance; quinoline-3-carboxamide; Anergy; Foxp3; iNOS; IFN-β; CD4 splenic DCs;

    Sammanfattning : The immune system is remarkable in many ways. It exerts immunity to defend us from foreign pathogens, while it is also responsible for maintaining tolerance to avoid autoimmune diseases and allergy. This thesis includes three separate papers concerning both tolerance and immunity. LÄS MER

  3. 2. Immuno-regulatory dynamics of non-structural protein 1 of avian influenza A viruses : IFN-β, NF-κB and AP-1 perspectives

    Författare :Muhammad Munir; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

    Sammanfattning : The type I interferon (IFN-α/β) system represents the first line of defense against influenza A viruses, and is mainly mediated by the interferon regulatory factors 3/7 (IRF3/7), nuclear factor kappa B (NF-κB) and activator protein 1 (AP-1) transcription factors. Therefore, the non-structural protein 1 (NS1) of influenza A viruses has intrinsic abilities to disarm the host cell IFN system, and as a consequence is deeply connected to influenza virus pathogenicity and virulence. LÄS MER

  4. 3. Role of classical pro- and anti-inflammatory mediators in ischemic stroke. Beyond neuroimmunomodulation

    Författare :Ana Inacio; Sektion IV; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; interferon-β; inflammatory immune cells; galectin-3; experimental stroke; enriched environment; cytokines; Brain; macrophage migration inhibitory factor; neuroprotection; reactive astrocytes.;

    Sammanfattning : Stroke is a leading cause of death and long-term neurological deficits worldwide, and no effective treatment is available for the vast majority of the stroke patients. A rapid and persistent activation of multiple and dynamic inflammatory and immune cascades, in and outside the brain, occurs after stroke. LÄS MER

  5. 4. HLA genetics in multiple sclerosis

    Författare :Jenny Link; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Multiple sclerosis (MS) is a chronic disease in which both genetic and environmental risk factors contribute to disease susceptibility. MS patients suffer from inflammatory lesions in the central nervous system which results in demyelination of nerve cells, reduced neuronal activity and finally neurodegeneration. LÄS MER

  7. 5. Initiation of Autoimmunity in Experimental Autoimmune Encephalomyelitis

    Författare :Magnus Isaksson; Anna Lobell; Olle Kämpe; William Agace; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Autoimmunity; Cytokines; Dendritic cells; DNA vaccination; EAE; Innate immunity; T helper cells; Toll-like receptors; Type I interferons; Molekylär medicin; Molecular Medicine;

    Sammanfattning : The events that trigger an autoimmune disease remain largely unknown. To study these events animal models are necessary because symptoms of autoimmune diseases are preceded by a long asymptomatic period in humans. LÄS MER