Sökning: "IAP"

Visar resultat 6 - 10 av 32 avhandlingar innehållade ordet IAP.

  1. 6. Smac and Smac mimetics in breast cancer cell death

    Författare :Christian Holmgren; Avdelningen för translationell cancerforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cell death; breast cancer; apoptosis; Smac mimetics; Smac; protein kinase C; TRAIL; IAP; TNFα;

    Sammanfattning : .... LÄS MER

  3. 7. Tumour Survival Signals and Epigenetic Gene Silencing in Multiple Myeloma : Implications for Biology and Therapy

    Författare :Charlotte Fristedt Duvefelt; Helena Jernberg-Wiklund; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Multiple myeloma; Polycomb; apoptosis; cIAP2; IAP-inbibitors; proteasome inhibitors; LBH589; PPP; DZNep;

    Sammanfattning : This thesis is focused on multiple myeloma (MM), a haematological malignancy that still remains incurable. The pathogenesis of MM is not fully understood and there is a large intra-tumour and interclonal genetic variation in MM patients. LÄS MER

  4. 8. Alterations in activity and specificity of intracellular proteolysis in disease pathogenesis

    Författare :Lei Lu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Proteasome; Ubiquitin; Cancer; Neuro-degeneration; Poly-Glutamine; Apoptosis; Tripeptidyl-Peptidase II; Stress; IAP;

    Sammanfattning : The ubiquitin-proteasome pathway (UPP) plays a fundamental role in many basic cellular processes. Virtually all events in cellular physiology include control by the ubiquitin-proteasome pathway. Ubiquitinated substrates are degraded by the 26S proteasome, a large multicatalytic protease complex. LÄS MER

  5. 9. Asymmetric lateral loading of the human trunk

    Författare :Qiang-Min Huang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Eccentric; concentric; isokinetic; electromyography; co-activation; trunk; spinal biomechanics; contraction patterns; lateral bending; lifting and lowering; balance; kinematics; postural control; IAP; support translation.;

    Sammanfattning : The overall aim of this thesis was to characterize the biomechanics and neuromuscular control of the human trunk in response to asymmetric lateral loading. The pulling force and strength capacities as well as muscle activation patterns, trunk kinematics and postural balance in relation to lateral trunk flexion and loading were given special consideration. LÄS MER

  7. 10. Human intestinal alkaline phosphatase : tissue expression and serum levels

    Författare :Ulla Domar; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Human alkaline phosphatase; intestinal alkaline phosphatase; blood; blood group; lipid; monoclonal antibody; immunohistochemistry; liver; kidney; pancreas; liver disease; inflammatory bowel disease;

    Sammanfattning : Human alkaline phosphatase (ALP) comprises four isozymes, viz liver/bone/ kidney or tissue unspecific (AP), intestinal (LAP), placental (PLAP) and germ cell or PLAP-like alkaline phosphatase, with their main expression in specific tissues as indicated by their names. The isozymes are coded by different genes, but they are closely related, with more than 50% amino acid sequence homologies. LÄS MER